Subsurface skin renewal by treatment with a 1450-nm laser in combination with dynamic cooling

A new nonablative laser device, Smoothbeam, has been under evaluation for nonablative wrinkle reduction in skin with minimal side effects. This device incorporates a laser at 1450-nm wavelength to heat the dermis and cryogen spray cooling to prevent epidermal damage. The thermal injury created is in...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2003-07, Vol.8 (3), p.545-551
Main Authors: Paithankar, Dilip Y, Clifford, Joan M, Saleh, Bilal A, Ross, E. Victor, Hardaway, Christina A, Barnette, David
Format: Article
Language:English
Subjects:
Breast - pathology
Breast - radiation effects
Burns - etiology
Burns - pathology
Burns - prevention & control
cryogen cooling
Cryotherapy - methods
Dermatologic Surgical Procedures
Dermis - injuries
Dermis - pathology
Dermis - radiation effects
Dermis - surgery
Epidermis - injuries
Epidermis - pathology
Epidermis - radiation effects
Hot Temperature - adverse effects
Hot Temperature - therapeutic use
Humans
Hypothermia, Induced - methods
In Vitro Techniques
Laser Therapy - adverse effects
Laser Therapy - methods
Models, Biological
Monte Carlo light transport modeling
nonablative wrinkle treatment
Rhytidoplasty - methods
Skin - injuries
Skin - pathology
Skin - radiation effects
Skin Aging - radiation effects
Therapy, Computer-Assisted - methods
Treatment Outcome
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Description
Summary:A new nonablative laser device, Smoothbeam, has been under evaluation for nonablative wrinkle reduction in skin with minimal side effects. This device incorporates a laser at 1450-nm wavelength to heat the dermis and cryogen spray cooling to prevent epidermal damage. The thermal injury created is internal and imperceptible. The wound-healing response to this internal injury causes improvement in the appearance of skin wrinkles. Biopsies taken immediately after treatment showed mild residual thermal damage (RTD) at a depth range of 150 to 400 m, which is the dermal zone where most solar elastosis resides. Biopsies from two months after treatment showed fibroplasia extending over a range of depths similar to the acute RTD zones. An improvement in wrinkle severity was noted on the treated side compared with the control side. ©
ISSN:1083-3668
1560-2281
DOI:10.1117/1.1586703