Mechanisms of membrane deformation

Membrane traffic requires the generation of high-curvature lipid-bound transport carriers represented by tubules and vesicles. The mechanisms through which membranes are deformed has gained much recent attention. A major advance has been the demonstration that direct interactions between cytosolic p...

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Bibliographic Details
Published in:Current opinion in cell biology 2003-08, Vol.15 (4), p.372-381
Main Authors: Farsad, Khashayar, Camilli, Pietro De
Format: Article
Language:English
Subjects:
Animals
Cell Compartmentation - physiology
Cytosol - metabolism
Humans
Intracellular Membranes - metabolism
Intracellular Membranes - ultrastructure
Membrane Lipids - metabolism
Membrane Proteins - metabolism
Microtubules - metabolism
Microtubules - ultrastructure
Peptides - metabolism
Transport Vesicles - metabolism
Transport Vesicles - ultrastructure
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Summary:Membrane traffic requires the generation of high-curvature lipid-bound transport carriers represented by tubules and vesicles. The mechanisms through which membranes are deformed has gained much recent attention. A major advance has been the demonstration that direct interactions between cytosolic proteins and lipid bilayers are important in the acquisition of membrane curvature. Rather than being driven only by the formation of membrane-associated structural scaffolds, membrane deformation requires physical perturbation of the lipid bilayer. A variety of proteins have been identified that directly bind and deform membranes. An emerging theme in this process is the importance of amphipathic peptides that partially penetrate the lipid bilayer.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(03)00073-5