Bovine monocytes induce immunoglobulin production in peripheral blood B lymphocytes

Although a role for monocytes and monocyte-derived dendritic cells (DC) in the activation of T cells is well established, it is less clear to what extent DC and their precursors, monocytes, regulate B cell immune responses. Here we show that regulatory mechanisms similar to those in humans are in pl...

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Bibliographic Details
Published in:Developmental and comparative immunology 2003-12, Vol.27 (10), p.889-897
Main Authors: Kruger, E.F, Boyd, B.L, Pinchuk, L.M
Format: Article
Language:English
Subjects:
Animals
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cattle
CD3 Complex - immunology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cell Aggregation
Cells, Cultured
Coculture Techniques
Dendritic cells
Flow Cytometry
Humans
Immunoglobulin A - immunology
Immunoglobulin A - metabolism
Immunoglobulin M - immunology
Immunoglobulin M - metabolism
Immunoglobulin secretion
Immunoglobulins - immunology
Immunoglobulins - metabolism
Isotype switching
Monocytes
Monocytes - cytology
Monocytes - metabolism
Progenitors
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Summary:Although a role for monocytes and monocyte-derived dendritic cells (DC) in the activation of T cells is well established, it is less clear to what extent DC and their precursors, monocytes, regulate B cell immune responses. Here we show that regulatory mechanisms similar to those in humans are in place in the bovine immune system. In vitro culture of bovine monocytes with bovine B cells activated by the anti-CD3 triggered CD4 + T cells or through immunoglobulin (Ig) receptor crosslinking induces B cell Ig secretion. Unlike bovine monocyte-derived DC, monocytes do not promote Ig class switching to IgG and IgA in activated peripheral blood B cells. These results suggest that bovine monocytes are capable of directly inducing Ig secretion in activated bovine peripheral blood B cells, but do not provide the signals for B cell Ig class switching.
ISSN:0145-305X
1879-0089
DOI:10.1016/S0145-305X(03)00080-6