Brain volume, asymmetry and intellectual impairment in relation to sex in early-onset schizophrenia

Accumulating evidence suggests that early-onset schizophrenia arises from a disturbance in the normal trajectory of cerebral development. To investigate brain structure, asymmetry and IQ in early-onset schizophrenia. Volumes of left and right cerebral hemispheres and IQ were assessed in 33 participa...

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Bibliographic Details
Published in:British journal of psychiatry 2003-08, Vol.183 (2), p.114-120
Main Authors: Collinson, Simon L., Mackay, Clare E., James, Anthony C., Quested, Digby J., Phillips, Tania, Roberts, Neil, Crow, Timothy J.
Format: Article
Language:English
Subjects:
Adolescent
Age
Age of onset
Asymmetries
Asymmetry
Brain - pathology
Brain hemispheres
Brain research
Brain structure
Cerebral hemispheres
Cerebral Ventricles - pathology
Cognition Disorders - etiology
Cognition Disorders - psychology
Control groups
Early onset
Female
Females
Gender differences
Hemispheric laterality
Humans
Intelligence
Intelligence quotient
Intelligence tests
Magnetic Resonance Imaging - methods
Male
Males
Medical diagnosis
Mental disorders
Patients
Psychiatry
Psychological Tests
Psychosis
Schizophrenia
Schizophrenia - complications
Schizophrenia - pathology
Schizophrenic Psychology
Sex Factors
Sexual dimorphism
Telencephalon - pathology
Temporal Lobe - pathology
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Summary:Accumulating evidence suggests that early-onset schizophrenia arises from a disturbance in the normal trajectory of cerebral development. To investigate brain structure, asymmetry and IQ in early-onset schizophrenia. Volumes of left and right cerebral hemispheres and IQ were assessed in 33 participants with early-onset DSM-IV schizophrenia and 30 members of a matched, normal control group. Total brain volume was significantly smaller in the group with early-onset disease ('cases') relative to the control group (4.5%), especially for the left hemisphere in males (6.0%). A significant sex x diagnosis interaction in hemisphere asymmetry revealed that the female cases group had significantly reduced rightward asymmetry relative to the female control group and that the male cases tended to have reduced leftward asymmetry relative to the male control group. Decreased left hemisphere volume in males and decreased rightward hemispheric asymmetry in females correlated with reduced IQ. Sexually dimorphic alterations in asymmetry correlate with degree of intellectual impairment in early-onset schizophrenia.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.183.2.114