Insulin sensitivity and cardiovascular risk factors in hypertensive and normotensive native Ghanaians

The objective of this study was to examine the relationships among insulin and insulin sensitivity and risk factors for cardiovascular diseases in native Ghanaians with and without hypertension. We measured the anthropometric parameters, systolic and diastolic blood pressure, fasting serum triglycer...

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Bibliographic Details
Published in:Diabetologia 2003-07, Vol.46 (7), p.949-955
Main Authors: AMOAH, A. G. B, SCHUSTER, D. P, GAILLARD, T, OSEI, K
Format: Article
Language:English
Subjects:
Adult
African Americans
Aged
Anthropometry
Biological and medical sciences
Blood Glucose - metabolism
Blood Pressure
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cholesterol
Diabetes
Fasting
Fundamental and applied biological sciences. Psychology
Ghana - epidemiology
Glucose
Glucose Tolerance Test
High density lipoprotein
Homeostasis
Humans
Hypertension
Hypertension - complications
Insulin - blood
Insulin - pharmacology
Insulin resistance
Insulin Resistance - physiology
Lipids
Lipoproteins
Lipoproteins - blood
Metabolic syndrome
Middle Aged
Obesity
Peptides
Reference Values
Regression Analysis
Risk Factors
Triglycerides
Triglycerides - blood
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Summary:The objective of this study was to examine the relationships among insulin and insulin sensitivity and risk factors for cardiovascular diseases in native Ghanaians with and without hypertension. We measured the anthropometric parameters, systolic and diastolic blood pressure, fasting serum triglycerides, cholesterol and high-density lipoprotein cholesterol and fasting and stimulated glucose, insulin and C-peptide of 200 Ghanaian subjects, who were between 25 to 74 years of age, and residing in the Accra Metropolitan area. Serum glucose, C-peptide and insulin concentrations were measured at baseline (fasting) and also 2 h after 75 gm oral glucose drink. Homeostasis model assessment was used to measure insulin resistance. Hypertension was defined as a blood pressure higher than 140/90 mmHg. There were 53 subjects with hypertension (HBP) and 147 subjects with normal blood pressure (NBP). The mean BMI, waist circumference and waist-to-hip circumference ratio for HBP and NBP subjects were 27.4+/-0.8, 24.8+/-0.4 kg/m(2); 89.8+/-11.7, 81.1+/-0.9 cm; and 0.87+/-0.08, 0.82+/-0.08 respectively, (p0.05). The corresponding fasting and 2-h insulin concentrations were 10.0+/-0.7, 8.0+/-0.4 uU/ml and 47.3+/-3.7, 37.3+/-2.5 uU/ml respectively (p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-003-1130-8