Improving the polymorphism content of the 3′ UTR of the human IGF2R gene

A tetranucleotide deletion/insertion polymorphism was identified within the 3' UTR of the human insulin-like growth factor II receptor gene (Accession number Y00285) close to a previously reported polymorphic dinucleotide repeat. Primers were chosen to amplify DNA fragments overlapping both pol...

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Bibliographic Details
Published in:Human molecular genetics 1992-08, Vol.1 (5), p.347-347
Main Authors: Hol, F.A., Geurds, M.P.A., Hamel, B.C.J., Mariman, E.C.M.
Format: Article
Language:English
Subjects:
Alleles
Base Sequence
Biological and medical sciences
Chromosomes, Human, Pair 6
Classical genetics, quantitative genetics, hybrids
DNA - genetics
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
genes
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
insulin-like growth factor II
Male
man
Molecular Sequence Data
Pedigree
Polymerase Chain Reaction
Polymorphism, Genetic
Receptor, IGF Type 2 - genetics
receptors
Repetitive Sequences, Nucleic Acid
restriction fragment length polymorphism
Sequence Deletion
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Summary:A tetranucleotide deletion/insertion polymorphism was identified within the 3' UTR of the human insulin-like growth factor II receptor gene (Accession number Y00285) close to a previously reported polymorphic dinucleotide repeat. Primers were chosen to amplify DNA fragments overlapping both polymorphic sites. Five alleles were observed in 60 unrelated Caucasians. The Heterozygosity was 58%. Co-dominant segregation was observed in seven informative families.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/1.5.347