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Patterns of responsiveness of T cell lines and thymocytes reveal waves of specific activity in the post-natal murine thymus
Antibody binding of CD3, CD4, or CD8 molecules can induce cytoplasmic calcium mobilization in T lymphocytes, usually Interpreted as indicating signal transduction. Using such assays, in a CD4+CD8+ thymocyte line and its single positive progeny we have Identified characteristic patterns of responsive...
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| Published in: | International immunology 1992-10, Vol.4 (10), p.1091-1101 |
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| Language: | English |
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| container_end_page | 1101 |
| container_issue | 10 |
| container_start_page | 1091 |
| container_title | International immunology |
| container_volume | 4 |
| creator | Morin, Cécile Jotereau, Francine Augustin, Andrei |
| description | Antibody binding of CD3, CD4, or CD8 molecules can induce cytoplasmic calcium mobilization in T lymphocytes, usually Interpreted as indicating signal transduction. Using such assays, in a CD4+CD8+ thymocyte line and its single positive progeny we have Identified characteristic patterns of responsiveness that are reproducible in vivo in a subpopulatlon of newborn ‘double positive’ thymocytes but virtually absent in adult thymuses. In particular, these cells appear to be high responders to the binding of anti-CD3 F(ab)'2 fragments. We have followed the presence of such highly responsive thymocytes in the perinatal period and the first 15 days of life. Intriguingly, these cells populate the newborn thymus in three distinct waves. Such patterns of responsiveness may define early ’selectable‘ thymocytes. |
| doi_str_mv | 10.1093/intimm/4.10.1091 |
| format | article |
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Using such assays, in a CD4+CD8+ thymocyte line and its single positive progeny we have Identified characteristic patterns of responsiveness that are reproducible in vivo in a subpopulatlon of newborn ‘double positive’ thymocytes but virtually absent in adult thymuses. In particular, these cells appear to be high responders to the binding of anti-CD3 F(ab)'2 fragments. We have followed the presence of such highly responsive thymocytes in the perinatal period and the first 15 days of life. Intriguingly, these cells populate the newborn thymus in three distinct waves. 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Psychology ; Fundamental immunology ; Hematopoietic Stem Cells - cytology ; Immunobiology ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Mice ; Mice, Inbred BALB C - immunology ; Moloney murine leukemia virus ; Signal Transduction ; stimulation Index ; T-Lymphocyte Subsets - immunology ; Thy 1+ lymphocytes ; thymocytes ; Thymoma - immunology ; Thymoma - microbiology ; Thymoma - pathology ; Thymus Gland - growth & development ; Thymus Gland - immunology ; Thymus Gland - pathology ; Thymus Neoplasms - immunology ; Thymus Neoplasms - microbiology ; Thymus Neoplasms - pathology</subject><ispartof>International immunology, 1992-10, Vol.4 (10), p.1091-1101</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-901131a131bf86f6dd65d320a700307ebbea95a650ef9399348fec9379d12f9e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4447464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1489728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morin, Cécile</creatorcontrib><creatorcontrib>Jotereau, Francine</creatorcontrib><creatorcontrib>Augustin, Andrei</creatorcontrib><title>Patterns of responsiveness of T cell lines and thymocytes reveal waves of specific activity in the post-natal murine thymus</title><title>International immunology</title><addtitle>Int Immunol</addtitle><description>Antibody binding of CD3, CD4, or CD8 molecules can induce cytoplasmic calcium mobilization in T lymphocytes, usually Interpreted as indicating signal transduction. Using such assays, in a CD4+CD8+ thymocyte line and its single positive progeny we have Identified characteristic patterns of responsiveness that are reproducible in vivo in a subpopulatlon of newborn ‘double positive’ thymocytes but virtually absent in adult thymuses. In particular, these cells appear to be high responders to the binding of anti-CD3 F(ab)'2 fragments. We have followed the presence of such highly responsive thymocytes in the perinatal period and the first 15 days of life. Intriguingly, these cells populate the newborn thymus in three distinct waves. Such patterns of responsiveness may define early ’selectable‘ thymocytes.</description><subject>Animals</subject><subject>Animals, Newborn - immunology</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>calcium mobilization</subject><subject>CD3 Complex - analysis</subject><subject>CD4 Antigens - analysis</subject><subject>CD8 Antigens - analysis</subject><subject>Cell Line, Transformed</subject><subject>Cell Movement</subject><subject>Clone Cells - immunology</subject><subject>cross-linking</subject><subject>F(ab) fragments</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Immunobiology</subject><subject>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</subject><subject>Mice</subject><subject>Mice, Inbred BALB C - immunology</subject><subject>Moloney murine leukemia virus</subject><subject>Signal Transduction</subject><subject>stimulation Index</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Thy 1+ lymphocytes</subject><subject>thymocytes</subject><subject>Thymoma - immunology</subject><subject>Thymoma - microbiology</subject><subject>Thymoma - pathology</subject><subject>Thymus Gland - growth & development</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - pathology</subject><subject>Thymus Neoplasms - immunology</subject><subject>Thymus Neoplasms - microbiology</subject><subject>Thymus Neoplasms - pathology</subject><issn>0953-8178</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqFkcFrFDEUxoModa3evQg5iLdpk0kmmRyl1K5acA8VpJeQzbxgdCYzJpnVpf-82Z2lHj2ER77v9z54fAi9puSCEsUufch-GC75xSLQJ2hFuSBVzaR8ilZENaxqqWyfoxcp_SCEsFqxM3RGeatk3a7Qw8bkDDEkPDocIU1jSH4HAdJRucMW-h73vgjYhA7n7_thtPtcvhF2YHr82-zgyKYJrHfeYmOz3_m8xz4UHvA0plwFkws8zLFEHVPm9BI9c6ZP8Oo0z9HXD9d3V-vq9svNx6v3t5VlROZKEUoZNeVtXSuc6DrRdKwmRpZziITtFoxqjGgIOMWUYrx1YBWTqqO1U8DO0bsld4rjrxlS1oNPh7tMgHFOWrKmJqIl_wWpYHUjBS0gWUAbx5QiOD1FP5i415ToQzF6KUbzk3BYeXPKnrcDdP8WliaK__bkm2RN76IJ1qdHjHMuueAFqxbMpwx_Hm0Tf2ohmWz0-tu9vm82m0-f1xtN2V-OgKiE</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>Morin, Cécile</creator><creator>Jotereau, Francine</creator><creator>Augustin, Andrei</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199210</creationdate><title>Patterns of responsiveness of T cell lines and thymocytes reveal waves of specific activity in the post-natal murine thymus</title><author>Morin, Cécile ; Jotereau, Francine ; Augustin, Andrei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-901131a131bf86f6dd65d320a700307ebbea95a650ef9399348fec9379d12f9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Animals, Newborn - immunology</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>calcium mobilization</topic><topic>CD3 Complex - analysis</topic><topic>CD4 Antigens - analysis</topic><topic>CD8 Antigens - analysis</topic><topic>Cell Line, Transformed</topic><topic>Cell Movement</topic><topic>Clone Cells - immunology</topic><topic>cross-linking</topic><topic>F(ab) fragments</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Immunobiology</topic><topic>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</topic><topic>Mice</topic><topic>Mice, Inbred BALB C - immunology</topic><topic>Moloney murine leukemia virus</topic><topic>Signal Transduction</topic><topic>stimulation Index</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Thy 1+ lymphocytes</topic><topic>thymocytes</topic><topic>Thymoma - immunology</topic><topic>Thymoma - microbiology</topic><topic>Thymoma - pathology</topic><topic>Thymus Gland - growth & development</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - pathology</topic><topic>Thymus Neoplasms - immunology</topic><topic>Thymus Neoplasms - microbiology</topic><topic>Thymus Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morin, Cécile</creatorcontrib><creatorcontrib>Jotereau, Francine</creatorcontrib><creatorcontrib>Augustin, Andrei</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morin, Cécile</au><au>Jotereau, Francine</au><au>Augustin, Andrei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of responsiveness of T cell lines and thymocytes reveal waves of specific activity in the post-natal murine thymus</atitle><jtitle>International immunology</jtitle><addtitle>Int Immunol</addtitle><date>1992-10</date><risdate>1992</risdate><volume>4</volume><issue>10</issue><spage>1091</spage><epage>1101</epage><pages>1091-1101</pages><issn>0953-8178</issn><eissn>1460-2377</eissn><abstract>Antibody binding of CD3, CD4, or CD8 molecules can induce cytoplasmic calcium mobilization in T lymphocytes, usually Interpreted as indicating signal transduction. Using such assays, in a CD4+CD8+ thymocyte line and its single positive progeny we have Identified characteristic patterns of responsiveness that are reproducible in vivo in a subpopulatlon of newborn ‘double positive’ thymocytes but virtually absent in adult thymuses. In particular, these cells appear to be high responders to the binding of anti-CD3 F(ab)'2 fragments. We have followed the presence of such highly responsive thymocytes in the perinatal period and the first 15 days of life. Intriguingly, these cells populate the newborn thymus in three distinct waves. Such patterns of responsiveness may define early ’selectable‘ thymocytes.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1489728</pmid><doi>10.1093/intimm/4.10.1091</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0953-8178 |
| ispartof | International immunology, 1992-10, Vol.4 (10), p.1091-1101 |
| issn | 0953-8178 1460-2377 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73520680 |
| source | Oxford University Press Archive |
| subjects | Animals Animals, Newborn - immunology Biological and medical sciences Calcium - metabolism calcium mobilization CD3 Complex - analysis CD4 Antigens - analysis CD8 Antigens - analysis Cell Line, Transformed Cell Movement Clone Cells - immunology cross-linking F(ab) fragments Fundamental and applied biological sciences. Psychology Fundamental immunology Hematopoietic Stem Cells - cytology Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Mice, Inbred BALB C - immunology Moloney murine leukemia virus Signal Transduction stimulation Index T-Lymphocyte Subsets - immunology Thy 1+ lymphocytes thymocytes Thymoma - immunology Thymoma - microbiology Thymoma - pathology Thymus Gland - growth & development Thymus Gland - immunology Thymus Gland - pathology Thymus Neoplasms - immunology Thymus Neoplasms - microbiology Thymus Neoplasms - pathology |
| title | Patterns of responsiveness of T cell lines and thymocytes reveal waves of specific activity in the post-natal murine thymus |
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