Fasting insulin concentration is highly correlated with quantitative insulin sensitivity check index

Given that the "gold standard" method for evaluating insulin sensitivity in vivo (hyperinsulinemic euglycemic glucose clamp technique) cannot be routinely applied because of technical reasons, simple methods and indexes were developed and are currently available to assess insulin sensitivi...

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Bibliographic Details
Published in:Endocrine 2003-07, Vol.21 (2), p.137-138
Main Authors: Hauache, Omar M, Vieira, José G H
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Fasting - blood
Female
Glucose Clamp Technique - methods
Glucose Intolerance - blood
Glucose Intolerance - diagnosis
Glucose Tolerance Test - methods
Humans
Insulin - blood
Male
Middle Aged
Obesity - blood
Reference Values
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Summary:Given that the "gold standard" method for evaluating insulin sensitivity in vivo (hyperinsulinemic euglycemic glucose clamp technique) cannot be routinely applied because of technical reasons, simple methods and indexes were developed and are currently available to assess insulin sensitivity in vivo. Quantitative insulin sensitivity check index (QUICKI) has recently been described and is able to accurately estimate insulin sensitivity from a fasting blood sample. We demonstrated that fasting insulin levels strongly inversely correlated with QUICKI in three different groups: 215 healthy nondiabetic nonobese subjects, 62 nondiabetic obese subjects, and 44 patients with glucose intolerance or type 2 diabetes mellitus. Fasting insulin measurement is a simple way of assessing insulin sensitivity in obese and nonobese humans, with or without glucose intolerance or type 2 diabetes mellitus.
ISSN:1355-008X
DOI:10.1385/ENDO:21:2:137