Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

It is widely accepted that both large-scale chromosomal abnormalities and mutation of specific genes, such as APC, K-ras, and/or p53, occur in the majority of colorectal adenocarcinomas. Whether or not a relationship exists between these different forms of genetic abnormalities was previously unknow...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2003-08, Vol.63 (15), p.4656-4661
Main Authors: LESLIE, Amy, PRATT, Norman R, GILLESPIE, Karen, SALES, Mark, KERNOHAN, Neil M, SMITH, Gillian, WOLF, C. Roland, CAREY, Francis A, STEELE, Robert J. C
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Aged
Aged, 80 and over
APC gene
Biological and medical sciences
Carrier Proteins
Chromosome Aberrations
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
DNA-Binding Proteins
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genes, APC
Genes, p53
Genes, ras
Genotype
Humans
Immunohistochemistry
K-ras gene
Male
Medical sciences
Middle Aged
Mutation
MutL Protein Homolog 1
MutS Homolog 2 Protein
Neoplasm Proteins - metabolism
Nuclear Proteins
Proto-Oncogene Proteins - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:It is widely accepted that both large-scale chromosomal abnormalities and mutation of specific genes, such as APC, K-ras, and/or p53, occur in the majority of colorectal adenocarcinomas. Whether or not a relationship exists between these different forms of genetic abnormalities was previously unknown. Using comparative genomic hybridization and mutational analysis of APC, K-ras, and p53 to evaluate 50 colorectal adenocarcinomas, we have shown that mutation of p53 is significantly associated with gain of 20q, 13q, and 8q and loss of 18q (P = 0.000, 0.02, 0.044, and 0.001, respectively). Conversely, APC mutation did not associate with any of the above-mentioned aberrations but did associate significantly with gain of 7p (P = 0.01). Gain of chromosomal arm 12p, although a less common aberration, was significantly associated with K-ras mutation (P = 0.011). The associations we have described should refine the search for candidate genes underlying chromosomal aberrations and assist in the definition of distinct pathways in colorectal tumorigenesis.
ISSN:0008-5472
1538-7445