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Effect of renal transplantation on sperm quality and sex hormone levels
OBJECTIVE To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial. PATIENTS AND METHODS Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morp...
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| Published in: | BJU international 2003-08, Vol.92 (3), p.281-283 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c4613-8530b3e7d7b5450e180b57064eee0d55fd83cd2b7786992ceccd25ffe12eef853 |
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| container_title | BJU international |
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| creator | Akbari, F. Alavi, M. Esteghamati, A. Mehrsai, A. Djaladat, H. Zohrevand, R. Pourmand, G. |
| description | OBJECTIVE
To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.
PATIENTS AND METHODS
Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5‐point scale. The paired t‐test was used to assess the statistically significance of differences in all analyses.
RESULTS
Sperm motility improved significantly (P |
| doi_str_mv | 10.1046/j.1464-410X.2003.04323.x |
| format | article |
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To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.
PATIENTS AND METHODS
Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5‐point scale. The paired t‐test was used to assess the statistically significance of differences in all analyses.
RESULTS
Sperm motility improved significantly (P < 0.001) but there were no significant changes in morphology or density (P = 0.33 and 0.068, respectively). Testosterone levels increased and FSH, LH and prolactin decreased significantly (P < 0.05) after renal transplantation. The IIEF showed that of the 30 patients, 14 were impotent before surgery and only six remained so afterward (P < 0.05).
CONCLUSION
Although sperm morphology and density did not improve after renal transplantation, there were highly significant changes in sperm motility. Hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal; sexual function was also significantly better. Further studies are needed to confirm these results.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1046/j.1464-410X.2003.04323.x</identifier><identifier>PMID: 12887484</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Combined surgery. Multiple transplantations ; Erectile Dysfunction - complications ; Follicle Stimulating Hormone - blood ; follicle‐stimulating hormone ; Gonadal Steroid Hormones - blood ; Humans ; impotence ; Kidney Failure, Chronic - surgery ; Kidney Transplantation ; luteinizing hormone ; Luteinizing Hormone - blood ; Male ; Medical sciences ; Middle Aged ; prolactin ; Prolactin - blood ; Renal Dialysis ; renal transplantation ; Sperm Motility - physiology ; Spermatozoa - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; testosterone ; Testosterone - blood</subject><ispartof>BJU international, 2003-08, Vol.92 (3), p.281-283</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4613-8530b3e7d7b5450e180b57064eee0d55fd83cd2b7786992ceccd25ffe12eef853</citedby><cites>FETCH-LOGICAL-c4613-8530b3e7d7b5450e180b57064eee0d55fd83cd2b7786992ceccd25ffe12eef853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15005265$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12887484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akbari, F.</creatorcontrib><creatorcontrib>Alavi, M.</creatorcontrib><creatorcontrib>Esteghamati, A.</creatorcontrib><creatorcontrib>Mehrsai, A.</creatorcontrib><creatorcontrib>Djaladat, H.</creatorcontrib><creatorcontrib>Zohrevand, R.</creatorcontrib><creatorcontrib>Pourmand, G.</creatorcontrib><title>Effect of renal transplantation on sperm quality and sex hormone levels</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVE
To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.
PATIENTS AND METHODS
Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5‐point scale. The paired t‐test was used to assess the statistically significance of differences in all analyses.
RESULTS
Sperm motility improved significantly (P < 0.001) but there were no significant changes in morphology or density (P = 0.33 and 0.068, respectively). Testosterone levels increased and FSH, LH and prolactin decreased significantly (P < 0.05) after renal transplantation. The IIEF showed that of the 30 patients, 14 were impotent before surgery and only six remained so afterward (P < 0.05).
CONCLUSION
Although sperm morphology and density did not improve after renal transplantation, there were highly significant changes in sperm motility. Hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal; sexual function was also significantly better. Further studies are needed to confirm these results.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Combined surgery. Multiple transplantations</subject><subject>Erectile Dysfunction - complications</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>follicle‐stimulating hormone</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Humans</subject><subject>impotence</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Transplantation</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>prolactin</subject><subject>Prolactin - blood</subject><subject>Renal Dialysis</subject><subject>renal transplantation</subject><subject>Sperm Motility - physiology</subject><subject>Spermatozoa - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>testosterone</subject><subject>Testosterone - blood</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0E4lH4BeQN7BLGsZ2kCxZQlZcqsaESO8txJiKVkxQ7hfbvcWiBLZKlGY_vHV8dQiiDmIFIrxYxE6mIBIPXOAHgMQie8Hi9R45_H_Z_ehinR-TE-wVAGKTykByxJM8zkYtjcj-tKjQ97SrqsNWW9k63fml12-u-7loajl-ia-j7Stu631DdltTjmr51rulapBY_0PpTclBp6_FsV0dkfjd9mTxEs-f7x8nNLDIiZTzKJYeCY1ZmhRQSkOVQyAxSgYhQSlmVOTdlUmRZno7HiUETbjJEZAliFdwjcrndu3Td-wp9r5raG7QhMHYrrzIuEz4OOEYk3wqN67x3WKmlqxvtNoqBGiCqhRr4qIGVGiCqb4hqHaznuz9WRYPln3FHLQgudgLtjbZVQGZq_6eTADJJh7DXW91nbXHz7wDq9mk-dPwLiV-NvQ</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Akbari, F.</creator><creator>Alavi, M.</creator><creator>Esteghamati, A.</creator><creator>Mehrsai, A.</creator><creator>Djaladat, H.</creator><creator>Zohrevand, R.</creator><creator>Pourmand, G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>Effect of renal transplantation on sperm quality and sex hormone levels</title><author>Akbari, F. ; Alavi, M. ; Esteghamati, A. ; Mehrsai, A. ; Djaladat, H. ; Zohrevand, R. ; Pourmand, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4613-8530b3e7d7b5450e180b57064eee0d55fd83cd2b7786992ceccd25ffe12eef853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Combined surgery. Multiple transplantations</topic><topic>Erectile Dysfunction - complications</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>follicle‐stimulating hormone</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Humans</topic><topic>impotence</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Transplantation</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>prolactin</topic><topic>Prolactin - blood</topic><topic>Renal Dialysis</topic><topic>renal transplantation</topic><topic>Sperm Motility - physiology</topic><topic>Spermatozoa - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbari, F.</creatorcontrib><creatorcontrib>Alavi, M.</creatorcontrib><creatorcontrib>Esteghamati, A.</creatorcontrib><creatorcontrib>Mehrsai, A.</creatorcontrib><creatorcontrib>Djaladat, H.</creatorcontrib><creatorcontrib>Zohrevand, R.</creatorcontrib><creatorcontrib>Pourmand, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akbari, F.</au><au>Alavi, M.</au><au>Esteghamati, A.</au><au>Mehrsai, A.</au><au>Djaladat, H.</au><au>Zohrevand, R.</au><au>Pourmand, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of renal transplantation on sperm quality and sex hormone levels</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2003-08</date><risdate>2003</risdate><volume>92</volume><issue>3</issue><spage>281</spage><epage>283</epage><pages>281-283</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>OBJECTIVE
To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.
PATIENTS AND METHODS
Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5‐point scale. The paired t‐test was used to assess the statistically significance of differences in all analyses.
RESULTS
Sperm motility improved significantly (P < 0.001) but there were no significant changes in morphology or density (P = 0.33 and 0.068, respectively). Testosterone levels increased and FSH, LH and prolactin decreased significantly (P < 0.05) after renal transplantation. The IIEF showed that of the 30 patients, 14 were impotent before surgery and only six remained so afterward (P < 0.05).
CONCLUSION
Although sperm morphology and density did not improve after renal transplantation, there were highly significant changes in sperm motility. Hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal; sexual function was also significantly better. Further studies are needed to confirm these results.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12887484</pmid><doi>10.1046/j.1464-410X.2003.04323.x</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Combined surgery. Multiple transplantations Erectile Dysfunction - complications Follicle Stimulating Hormone - blood follicle‐stimulating hormone Gonadal Steroid Hormones - blood Humans impotence Kidney Failure, Chronic - surgery Kidney Transplantation luteinizing hormone Luteinizing Hormone - blood Male Medical sciences Middle Aged prolactin Prolactin - blood Renal Dialysis renal transplantation Sperm Motility - physiology Spermatozoa - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases testosterone Testosterone - blood |
| title | Effect of renal transplantation on sperm quality and sex hormone levels |
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