Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system

Glucocorticoids (GCs) play an essential role in the maintenance of homeostasis. In normal circumstances their secretion is tightly regulated by a complex servo mechanism through which the steroids suppress the synthesis and release of ACTH and its hypothalamic releasing factors (CRH and AVP) and the...

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Bibliographic Details
Published in:Cell biochemistry and function 2003-09, Vol.21 (3), p.217-221
Main Authors: Buckingham, Julia C., Solito, Egle, John, Christopher, Tierney, Tanya, Taylor, Amanda, Flower, Rod, Christian, Helen, Morris, John
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - physiology
Amino Acid Sequence
Animals
annexin 1
Annexin A1 - genetics
Annexin A1 - physiology
Arginine Vasopressin - physiology
Autocrine Communication - physiology
corticotrophin (ACTH)
Corticotropin-Releasing Hormone - physiology
Feedback, Physiological - physiology
glucocorticoids
Glucocorticoids - physiology
Humans
Hypothalamo-Hypophyseal System - physiology
hypothalamus
Models, Biological
Molecular Sequence Data
Neurosecretory Systems - physiology
Paracrine Communication - physiology
pituitary
Pituitary-Adrenal System - physiology
Rats
Signal Transduction - physiology
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Summary:Glucocorticoids (GCs) play an essential role in the maintenance of homeostasis. In normal circumstances their secretion is tightly regulated by a complex servo mechanism through which the steroids suppress the synthesis and release of ACTH and its hypothalamic releasing factors (CRH and AVP) and thereby reduce the positive drive to the adrenal cortex. The feedback actions of GCs on hormone release develop rapidly (within minutes), well before any changes in hormone synthesis are apparent. By using immunoneutralization, gene targeting and pharmacological strategies in in vivo and in vitro models, we have identified annexin 1, a Ca2+‐ and phospholipid‐binding protein, as a key mediator of the early inhibitory actions of GCs on peptide release. This brief review outlines this work and describes molecular and cellular studies which have provided insight into the mechanism of annexin 1‐dependent GC signalling in the neuroendocrine system. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.1076