Drosophila metabolize 1,4-butanediol into γ-hydroxybutyric acid in vivo

A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into γ-hydroxybutyric acid (GHB), which stimulates metabotropic γ-aminobutyric acid (GABA) GABAB and putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Dr...

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Bibliographic Details
Published in:European journal of pharmacology 2003-07, Vol.473 (2-3), p.149-152
Main Authors: Satta, Rosalba, Dimitrijevic, Nikola, Manev, Hari
Format: Article
Language:English
Subjects:
Animals
Behavior
Biological and medical sciences
Butylene Glycols - metabolism
Drosophila melanogaster - metabolism
Fruit fly
GABA (γ-aminoybutyric acid)
Gas Chromatography-Mass Spectrometry
GHB (γ-hydroxybutyric acid)
Male
Medical sciences
Sodium Oxybate - metabolism
Time Factors
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Summary:A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into γ-hydroxybutyric acid (GHB), which stimulates metabotropic γ-aminobutyric acid (GABA) GABAB and putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1–2 h later). This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(03)01993-9