A validated spectrofluorometric method for the determination of celecoxib in capsules

A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355+/-5 nm (ex...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2003-08, Vol.376 (7), p.1141-1146
Main Authors: Damiani, Patricia, Bearzotti, Mariela, Cabezón, Miguel A
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - analysis
Calibration
Capsules
Celecoxib
Indicators and Reagents
Molecular Structure
Pyrazoles
Reproducibility of Results
Spectrometry, Fluorescence - methods
Sulfonamides - analysis
Sulfonamides - chemistry
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Summary:A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355+/-5 nm (exciting at 272 nm). The method was fully validated and the recoveries were excellent, even in presence of excipients.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-003-1975-1