A validated spectrofluorometric method for the determination of celecoxib in capsules

A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355+/-5 nm (ex...

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Published in:Analytical and bioanalytical chemistry 2003-08, Vol.376 (7), p.1141-1146
Main Authors: Damiani, Patricia, Bearzotti, Mariela, Cabezón, Miguel A
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - analysis
Calibration
Capsules
Celecoxib
Indicators and Reagents
Molecular Structure
Pyrazoles
Reproducibility of Results
Spectrometry, Fluorescence - methods
Sulfonamides - analysis
Sulfonamides - chemistry
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cited_by cdi_FETCH-LOGICAL-c297t-af55d0b68cc0d030d70ea4e41df5eb90d1e9f004b962b71bfe72c02c1a2f5e233
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container_title Analytical and bioanalytical chemistry
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creator Damiani, Patricia
Bearzotti, Mariela
Cabezón, Miguel A
description A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355+/-5 nm (exciting at 272 nm). The method was fully validated and the recoveries were excellent, even in presence of excipients.
doi_str_mv 10.1007/s00216-003-1975-1
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subjects Anti-Inflammatory Agents, Non-Steroidal - analysis
Calibration
Capsules
Celecoxib
Indicators and Reagents
Molecular Structure
Pyrazoles
Reproducibility of Results
Spectrometry, Fluorescence - methods
Sulfonamides - analysis
Sulfonamides - chemistry
title A validated spectrofluorometric method for the determination of celecoxib in capsules
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