Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model

Endothelium-dependent G-protein mediated relaxations of epicardial coronary arteries is impaired with left ventricular hypertrophy. The objective of this study was to assess the effect of L-arginine, BH(4) and the combination of two antioxidants, superoxide dismutase and catalase, on endothelium-dep...

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Bibliographic Details
Published in:Cardiovascular research 2003-08, Vol.59 (2), p.501-511
Main Authors: MALO, Olivier, DESJARDINS, Fanny, TANGUAY, Jean-Francois, TARDIF, Jean-Claude, CARRIER, Michel, PERRAULT, Louis P
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Arginine - pharmacology
Biological and medical sciences
Biomarkers - blood
Bradykinin - pharmacology
Cardiology. Vascular system
Catalase - pharmacology
Coronary Vessels
Dose-Response Relationship, Drug
Echocardiography
Endothelium, Vascular - drug effects
Female
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - physiopathology
In Vitro Techniques
Ketanserin - pharmacology
Male
Medical sciences
Models, Animal
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type III
Oxidative Stress
Peroxynitrous Acid - blood
Pterins - pharmacology
Serotonin - pharmacology
Serotonin Antagonists - pharmacology
Superoxide Dismutase - pharmacology
Swine
Tyrosine - analogs & derivatives
Tyrosine - blood
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Summary:Endothelium-dependent G-protein mediated relaxations of epicardial coronary arteries is impaired with left ventricular hypertrophy. The objective of this study was to assess the effect of L-arginine, BH(4) and the combination of two antioxidants, superoxide dismutase and catalase, on endothelium-dependent relaxations in a swine left ventricular hypertrophy model. Aortic banding was performed 3 cm above the coronary ostia. Vascular reactivity studies were performed in standard organ chamber experiments to assess the NO pathway in the presence of methyltetrahydropterin (a BH(4) analogue), L-arginine, superoxide dismutase and catalase. There was a statistically significant increase in endothelium-dependent relaxation to serotonin and to bradykinin with methyltetrahydropterin and with superoxide dismutase plus catalase (P
ISSN:0008-6363
1755-3245
DOI:10.1016/S0008-6363(03)00390-0