The role of dendritic cell subsets in immunity to viruses

Dendritic cells orchestrate the adaptive immune response. As well as presenting MHC-restricted antigen for T-cell activation, they provide all the co-receptor signals required for full T-cell priming. As a consequence, they play a central role in the immune response to infections caused by many path...

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Bibliographic Details
Published in:Current opinion in immunology 2003-08, Vol.15 (4), p.416-420
Main Authors: Carbone, Francis R, Heath, William R
Format: Article
Language:English
Subjects:
Animals
Dendritic Cells - classification
Dendritic Cells - immunology
Dendritic Cells - virology
Humans
Immunity, Innate - immunology
T-Lymphocytes - immunology
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Summary:Dendritic cells orchestrate the adaptive immune response. As well as presenting MHC-restricted antigen for T-cell activation, they provide all the co-receptor signals required for full T-cell priming. As a consequence, they play a central role in the immune response to infections caused by many pathogenic agents, including viruses. In recent times, it has become apparent that dendritic cells represent a particularly heterogeneous population with individual subsets playing specialized roles in response to infection.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(03)00074-8