Estrogen receptor alpha gene polymorphisms and breast cancer risk

We conducted a hospital-based case-control study to evaluate the association between the XbaI and PvuII restriction fragment length polymorphisms (RFLPs) in intron I of the estrogen receptor alpha (ER alpha) gene and breast cancer risk. The study population consisted of 205 histologically confirmed...

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Bibliographic Details
Published in:Breast cancer research and treatment 2003-07, Vol.80 (1), p.127-131
Main Authors: SHIN, Aesun, KANG, Daehee, JU HAN KIM, YOO, Keun-Young, NISHIO, Hisahide, MYEONG JIN LEE, SUE KYUNG PARK, KIM, Sook-Un, NOH, Dong-Young, CHOE, Kuk-Jin, AHN, Se-Hyun, HIRVONEN, Ari
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Asian people
Biological and medical sciences
Breast cancer
Breast Neoplasms - genetics
Cancer research
Cancer therapies
Case-Control Studies
Estrogen Receptor alpha
Estrogens
Female
Genes
Genetic Predisposition to Disease
Genetics
Genotype
Gynecology. Andrology. Obstetrics
Health risk assessment
Humans
Mammary gland diseases
Medical sciences
Menopause
Middle Aged
Odds Ratio
Polymorphism, Restriction Fragment Length
Receptors, Estrogen - genetics
Risk Assessment
Risk Factors
Tumors
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Summary:We conducted a hospital-based case-control study to evaluate the association between the XbaI and PvuII restriction fragment length polymorphisms (RFLPs) in intron I of the estrogen receptor alpha (ER alpha) gene and breast cancer risk. The study population consisted of 205 histologically confirmed incident breast cancer cases and 205 age-matched controls with no present and previous history of cancer. The PvuII genotype distribution did not show any difference between cases and controls, but the adjusted odds ratio (OR) for the XbaI X allele containing genotypes was 0.4 (95% CI: 0.3-0.6) compared with the xx genotype. The decrease in the OR appeared to be more attributable to the postmenopausal women; the ORs were 0.3 (95% CI: 0.1-0.5) and 0.5 (95% CI: 0.3-0.9) for postmenopausal and premenopausal women, respectively. Our results therefore suggest that the ER alpha XbaI polymorphism modifies individual susceptibility to breast cancer in Korean women.
ISSN:0167-6806
1573-7217
DOI:10.1023/A:1024439202528