Circulating numbers of endothelial progenitor cells in patients with gastric and breast cancer

Angiogenic factors like VEGF or G-CSF were reported to mobilize endothelial progenitor cells (EPCs) from the bone marrow. These EPCs were shown to be incorporated in the neovessels of developing tumors. Although the concentrations of angiogenic factors in the peripheral blood were reported to be ele...

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Bibliographic Details
Published in:Cancer letters 2003-07, Vol.198 (1), p.83-88
Main Authors: Kyung Kim, Hyun, Soon Song, Kyung, Ok Kim, Hyun, Chung, Jun-Ho, Rhan Lee, Kyoung, Lee, Young-Joon, Ho Lee, Dae, Sook Lee, Eun, Kyun Kim, Hark, Won Ryu, Keun, Bae, Jae-Moon
Format: Article
Language:English
Subjects:
Age
Angiogenic factor
Antineoplastic agents
Biological and medical sciences
Bone marrow
Breast cancer
Breast Neoplasms - blood supply
Endothelial Growth Factors - blood
Endothelial progenitor cells
Endothelium - cytology
Female
Flow cytometry
Gastric cancer
Heart attacks
Humans
Intercellular Signaling Peptides and Proteins - blood
Lectins
Lymphokines - blood
Male
Medical sciences
Middle Aged
Mobilization
Myeloid Progenitor Cells
Pharmacology. Drug treatments
Plasma
Regression analysis
Rodents
Statistical analysis
Stomach Neoplasms - blood supply
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:Angiogenic factors like VEGF or G-CSF were reported to mobilize endothelial progenitor cells (EPCs) from the bone marrow. These EPCs were shown to be incorporated in the neovessels of developing tumors. Although the concentrations of angiogenic factors in the peripheral blood were reported to be elevated in cancer patients, the number of circulating EPCs has not been previously investigated. In this study, the number of EPCs circulating in the blood in 16 healthy controls and 71 newly diagnosed cancer patients was examined by a culture assay of peripheral blood mononuclear cells. The number of circulating EPCs was not found to be increased in cancer patients, although the plasma levels of VEGF were elevated. It is suggested that VEGF, at concentrations typical of those observed in the blood of cancer patients, does not mobilize EPCs into the peripheral blood.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(03)00268-4