Developments in microarray technologies

The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analy...

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Bibliographic Details
Published in:Drug Discovery Today 2003-07, Vol.8 (14), p.642-651
Main Authors: Howbrook, David N., van der Valk, Anne M., O'Shaughnessy, Meg C., Sarker, Dipak K., Baker, Simon C., Lloyd, Andrew W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
DNA microarrays
Gene Expression Profiling
glycome
high-throughput screening
Medical sciences
metabolome
microarray
microfluidics
nanotechnology
Nanotechnology - methods
Nanotechnology - trends
Oligonucleotide Array Sequence Analysis - methods
proteome
Space life sciences
Technology, Pharmaceutical - trends
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Summary:The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analysis; however, they are also used to screen libraries of proteins and small molecules. Microarrays have helped to extract more information from smaller sample volumes and enabled the incorporation of low-cost high-throughput assays in the drug discovery process. The technology continues to develop and is being rapidly transferred into more challenging areas, with the potential to further aid and enhance the drug discovery process through the development of, for example, proteomic, glycomic and tissue arrays. Microarray technology continues to develop and has the potential to further aid and advance the drug discovery process through thte development of, for example, proteomic, glycomic and tissue arrays.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(03)02773-9