Effect of pericardial fluid pro-inflammatory cytokines on hemodynamic parameters

We investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group 1, stable angina pectoris (SAP, n=15); group 2, un...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2003-07, Vol.23 (1), p.47-51
Main Authors: Ege, Turan, Canbaz, Suat, Yuksel, Volkan, Duran, Enver
Format: Article
Language:English
Subjects:
Analysis of Variance
Cardiac Output - physiology
coronary artery
Coronary artery bypass surgery
Cytokines - metabolism
Female
Heart - physiology
Hemodynamics - physiology
Humans
Interleukin
Interleukin 1^b
Interleukin-1 - metabolism
Male
Middle Aged
Pericardial cytokines
Pericardial fluid
Pericardium - metabolism
Tumor necrosis factor
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Summary:We investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group 1, stable angina pectoris (SAP, n=15); group 2, unstable angina pectoris (USAP, n=34); group 3, post-myocardial infarction (PMI, n=29). Pericardial fluid and arterial blood samples were obtained from all patients and interleukin (IL)-1β, IL-2 receptor, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-α) levels were measured. Pericardial IL-1β concentration (pg/mL) was significantly higher in the USAP group (26.6 ± 10.9) compared to the SAP (5.0 ± 0.1) and PMI (5.8 ± 1.0) groups. IL-2R, IL-6, IL-8 and TNF-α concentrations of pericardial fluid were significantly higher than serum in all groups; difference was more prominent in the PMI group compared to the SAP and the USAP groups. Serum IL-1β concentrations (pg/mL) were significantly higher in the USAP group (21.8 ± 3.4) compared to the SAP group (5.0 ± 0.1) and the PMI group (5.4 ± 1.6). Cardiac index (CI) before opening the pericardial sac was found to be lower in the USAP group (1.6 ± 0.3 L/min/m 2) compared to the SAP (2.2 ± 0.5 L/min/m 2) and the PMI (2.1 ± 0.5 L/min/m 2) groups ( p=0.028 and p=0.011, respectively). In the USAP group, there was a relationship between reduction of CI and increase of IL-1β levels in serum and pericardial fluid.
ISSN:1043-4666
1096-0023
DOI:10.1016/S1043-4666(03)00180-7