Analytical methods for the quantitative determination of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in biological samples

Published analytical methods for the quantitative determinations of presently available five 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (“statins”), lovastatin, simvastatin, pravastatin, fluvastatin and atorvastatin, are reviewed for therapeutic drug monitoring purpose in patients. A...

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Bibliographic Details
Published in:Journal of Chromatography B 2003-08, Vol.793 (2), p.193-205
Main Authors: Ertürk, Sidika, Onal, Armağan, Müge Cetin, Sevil
Format: Article
Language:English
Subjects:
3-Hydroxy-3-methylglutaryl
Analysis
Biological and medical sciences
Drug Monitoring
General pharmacology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Medical sciences
Pharmacology. Drug treatments
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Summary:Published analytical methods for the quantitative determinations of presently available five 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (“statins”), lovastatin, simvastatin, pravastatin, fluvastatin and atorvastatin, are reviewed for therapeutic drug monitoring purpose in patients. Almost all assay reviewed are based on high-performance liquid chromatography or gas chromatography. Some purification steps (liquid–liquid extraction, solid-phase extraction, etc.) have been used before they are submitted to separation by chromatographic procedures and they are detected by various detection methods like UV, fluorescence and mass spectrometry. This review shows that most method may be used quantitative determination of statins in plasma and they are suitable for therapeutic drug monitoring purpose of these drugs.
ISSN:1570-0232
1873-376X
DOI:10.1016/S1570-0232(03)00314-3