Genetics and ontogeny of butyryl CoA dehydrogenase in the mouse and linkage of Bcd-1 with Dao-1

A zymogram method has been developed for fatty acyl CoA dehydrogenase and used to examine the electrophoretic properties of butyryl CoA dehydrogenase (BCD) from mouse tissues. A single form of BCD is present in extracts of liver, kidney, heart, and intestine. Ontogenetic, tissue distribution, and su...

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Bibliographic Details
Published in:Biochemical genetics 1981-04, Vol.19 (3-4), p.333-345
Main Authors: Seeley, T L, Holmes, R S
Format: Article
Language:English
Subjects:
Acyl-CoA Dehydrogenases - genetics
Alleles
Animals
Butyryl-CoA Dehydrogenase
Genetic Linkage
Isoenzymes - genetics
Kidney - enzymology
Liver - enzymology
Mice
Myocardium - enzymology
Species Specificity
Subcellular Fractions - enzymology
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Summary:A zymogram method has been developed for fatty acyl CoA dehydrogenase and used to examine the electrophoretic properties of butyryl CoA dehydrogenase (BCD) from mouse tissues. A single form of BCD is present in extracts of liver, kidney, heart, and intestine. Ontogenetic, tissue distribution, and subcellular fractionation results are consistent with the mitochondrial origin previously reported for this enzyme. A genetic variant for BCD-1 was used to provide evidence for a locus determining the electrophoretic properties of this enzyme (designated Bcd-1), which is linked to Dao-1 (encoding D-amino acid oxidase).
ISSN:0006-2928
1573-4927
DOI:10.1007/BF00504278