Antibiotic tolerance in strains of Staphylococcus aureus

The frequency of tolerance in 13 strains of Staphylococcus aureus was examined .using two media (MHB and BHI broth) and two methods (broth dilution and time-kill curves). In broth dilution tests, tolerance was found more frequently in MHB than BHI; a similar, but much smaller effect was noted in tim...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1981-06, Vol.7 (6), p.599-605
Main Authors: Norden, Carl W., Keleti, Eva
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Drug Resistance, Microbial
Humans
Microbial Sensitivity Tests
Staphylococcal Infections - microbiology
Staphylococcus aureus - drug effects
Time Factors
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Summary:The frequency of tolerance in 13 strains of Staphylococcus aureus was examined .using two media (MHB and BHI broth) and two methods (broth dilution and time-kill curves). In broth dilution tests, tolerance was found more frequently in MHB than BHI; a similar, but much smaller effect was noted in time-kill curves. There were also discrepancies (with both BHI and MHB) between the two methods of testing as to whether a strain was called tolerant. The significance of these technical variations will probably require correlation with clinical studies to determine the most useful methods of testing for tolerance.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/7.6.599