Characterization of viro‐immunological responses in a closely followed cohort of heavily pretreated patients: evidence from the GenPheRex Study

• Published in: HIV medicine 2003-07, Vol.4 (3), p.263-270
• Main Authors: Torti, C, Quiros‐Roldan, E, Scudeller, L, Lo Caputo, S, Tomasoni, L, Castelli, F, Poggio, A, Delle Foglie, P, Chirianni, A, Sighinolfi, L, Mazzotta, F, Carosi, G
• Format: Article
• Language: English
• Subjects: Anti-HIV Agents - therapeutic use; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Disease Progression; highly active antiretroviral therapy; HIV; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV Protease Inhibitors - therapeutic use; HIV-1 - isolation & purification; Humans; immunologic recovery; Linear Models; Logistic Models; Phenotype; Prospective Studies; Risk Factors; RNA, Viral - blood; Salvage Therapy; Viral Load
• ISSN: 1464-2662; 1468-1293
• DOI: 10.1046/j.1468-1293.2003.00154.x

Objectives  To assess prevalence and predictive factors of viro‐immunological discordant trends in a cohort of heavily pretreated patients. Methods  Factors associated with viro‐immunological discordant trends either as categorical or continuous measures have been studied in 159 heavily pretreated HIV‐positive patients from a multicentre prospective study of real‐ vs. virtual‐phenotype. Univariate and multivariate logistic regressions were used to assess risk factors for categorical discordant responses, ceasing follow‐up at week 32 since enough patients had been on the original drug combination for a sufficient amount of time to evaluate their immune response. Complementary linear regression analysis was performed over the entire 48 weeks' follow‐up considering CD4 and plasma viral load (pVL) as continuous measures. Results  Among 58 virological responder patients (≥1 log10 HIV‐1 RNA copies/mL decrease) and 101 virologically non‐responders, immunological discordances (increase in CD4 count of