Asymptomatic Infection with Borrelia burgdorferi

The natural history of asymptomatic seroconversion to Borrelia burgdorferi has been unclear. We report here, on the basis of a post hoc assessment, the frequency and outcome of asymptomatic seroconversion to B. burgdorferi in participants of a large Lyme disease vaccine trial. We show that infection...

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Bibliographic Details
Published in:Clinical infectious diseases 2003-08, Vol.37 (4), p.528-532
Main Authors: Steere, Allen C., Sikand, Vijay K., Schoen, Robert T., Nowakowski, John
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies
Asymptomatic infections
Bacterial diseases
Biological and medical sciences
Borrelia burgdorferi
Borrelia burgdorferi - immunology
Borrelia infections
Double-Blind Method
Enzyme linked immunosorbent assay
Erythema
Female
Human bacterial diseases
Humans
Infections
Infectious diseases
Lyme disease
Lyme Disease - epidemiology
Lyme Disease - immunology
Lyme Disease - physiopathology
Lyme Disease - prevention & control
Lyme Disease Vaccines - administration & dosage
Lyme Disease Vaccines - adverse effects
Lyme Disease Vaccines - immunology
Major Articles
Male
Medical sciences
Middle Aged
Prevalence
Statistical median
Symptoms
Treatment Outcome
Tropical bacterial diseases
Vaccination
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Description
Summary:The natural history of asymptomatic seroconversion to Borrelia burgdorferi has been unclear. We report here, on the basis of a post hoc assessment, the frequency and outcome of asymptomatic seroconversion to B. burgdorferi in participants of a large Lyme disease vaccine trial. We show that infection with B. burgdorferi may be asymptomatic but that asymptomatic infection is unusual in the United States.
ISSN:1058-4838
1537-6591
DOI:10.1086/376914