Photodynamic inhibition of infection caused by drug-resistant variants of herpes simplex virus type I

Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentrat...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-04, Vol.135 (4), p.384-387
Main Authors: Kvacheva, Z B, Shukanova, N A, Votyakov, V I, Lobanok, E S, Vorobei, A V, Nikolaeva, S N
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - pharmacology
Cercopithecus aethiops
Drug Resistance, Viral
Herpes Simplex
Herpesvirus 1, Human - drug effects
Humans
Photosensitizing Agents - pharmacology
Pyrimidinones - pharmacology
Vero Cells
Virus Replication
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Summary:Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentration 1 microM, illumination dose 32.5-65.0 kJ/m(2), exposure at early stages of infection). Infected cells actively bind the photosensitizer, which explains their selective photodamage.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1024625201337