Locoregional opening of the rodent blood-brain barrier for paclitaxel using Nd:YAG laser-induced thermo therapy: A new concept of adjuvant glioma therapy?

Background and Objectives Nd:YAG laser‐induced thermo therapy (LITT) of rat brains is associated with blood–brain barrier (BBB) permeability changes. We address the question of whether LITT‐induced locoregional disruption of the BBB could possibly allow a locoregional passage of chemotherapeutic age...

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Published in:Lasers in surgery and medicine 2003-01, Vol.33 (2), p.75-80
Main Authors: Sabel, Michael, Rommel, Frank, Kondakci, Mustafa, Gorol, Marion, Willers, Reinhard, Bilzer, Thomas
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Antineoplastic agents
Antineoplastic Agents, Phytogenic - administration & dosage
Biological and medical sciences
Blood-Brain Barrier - physiopathology
Blood-Brain Barrier - surgery
Brain Neoplasms - drug therapy
Chemotherapy
Chemotherapy, Adjuvant - methods
Glioma - drug therapy
HPLC
Hyperthermia, Induced - methods
immunohistochemistry
Laser Therapy - methods
LITT
Medical sciences
Neurosurgical Procedures - methods
Paclitaxel - administration & dosage
Permeability - radiation effects
Pharmacology. Drug treatments
Rats
Rats, Inbred F344
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Summary:Background and Objectives Nd:YAG laser‐induced thermo therapy (LITT) of rat brains is associated with blood–brain barrier (BBB) permeability changes. We address the question of whether LITT‐induced locoregional disruption of the BBB could possibly allow a locoregional passage of chemotherapeutic agents into brain tissue to treat malignant glioma. Study Design/Materials and Methods CD Fischer rats were subject to LITT of the left forebrain. Disruption of the BBB was analyzed using Evans blue and immunohistochemistry (IH). Animals were perfused with paclitaxel, and high‐pressure liquid chromatography (HPLC) was employed to analyze the content of paclitaxel in brain and plasma samples. Results LITT induces an opening of the BBB as demonstrated by locoregional extravasation of Evans blue, C3C, fibrinogen, and IgM. HPLC proved the passage of paclitaxel across the disrupted BBB. Conclusions LITT induces a locoregional passage of chemotherapeutic agents into the brain tissue. This is of potential interest for the treatment of brain tumors. Lasers Surg. Med. 33:75–80, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.10181