The Asymmetric Intramolecular Heck Reaction in Natural Product Total Synthesis

The Pd(0)-catalyzed vinylation of aryl halides was first reported over 30 years ago in independent studies by Mizoroki and Heck. The transformation that has come to be known as the Heck reaction is now broadly defined as the Pd(0)-mediated coupling of an aryl or vinyl halide or triflate with an alke...

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Bibliographic Details
Published in:Chemical reviews 2003-08, Vol.103 (8), p.2945-2964
Main Authors: Dounay, Amy B, Overman, Larry E
Format: Article
Language:English
Subjects:
Alkaloids - chemical synthesis
Biological Factors - chemical synthesis
Catalysis
Cations
Chemical reactions
Organic chemistry
Stereoisomerism
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Summary:The Pd(0)-catalyzed vinylation of aryl halides was first reported over 30 years ago in independent studies by Mizoroki and Heck. The transformation that has come to be known as the Heck reaction is now broadly defined as the Pd(0)-mediated coupling of an aryl or vinyl halide or triflate with an alkene.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr020039h