Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study

Conventional wisdom suggests that a diagnosis of familial combined hyperlipidemia (FCHL) carries a substantially greater risk of premature coronary artery disease (CAD) than a diagnosis of familial hypertriglyceridemia (FHTG). However, no population-based studies have critically addressed this issue...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-08, Vol.108 (5), p.519-523
Main Authors: Hopkins, Paul N, Heiss, Gerardo, Ellison, R Curtis, Province, Michael A, Pankow, James S, Eckfeldt, John H, Hunt, Steven C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cholesterol, HDL - blood
Comorbidity
Coronary Artery Disease - epidemiology
Diabetes Mellitus - epidemiology
Family
Female
Humans
Hyperlipidemias - diagnosis
Hyperlipidemias - epidemiology
Hyperlipidemias - genetics
Hypertension - epidemiology
Hypertriglyceridemia - diagnosis
Hypertriglyceridemia - epidemiology
Hypertriglyceridemia - genetics
Logistic Models
Male
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Middle Aged
Multicenter Studies as Topic - statistics & numerical data
Odds Ratio
Risk Assessment
Risk Factors
Triglycerides - blood
United States - epidemiology
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Summary:Conventional wisdom suggests that a diagnosis of familial combined hyperlipidemia (FCHL) carries a substantially greater risk of premature coronary artery disease (CAD) than a diagnosis of familial hypertriglyceridemia (FHTG). However, no population-based studies have critically addressed this issue. FCHL and FHTG were diagnosed in 10.2% and 12.3% of 334 random control families and in 16.7% and 20.5% of 293 families with at least one case of premature CAD. The diagnosis of either FCHL or FHTG in an individual was associated with an odds ratio for CAD of 2.0 (P=0.003 and 0.002, respectively). However, odds ratios for premature CAD associated with both lipid disorders decreased substantially and identically with further adjustment for hypertension, diabetes, and especially HDL cholesterol, triglycerides, or apolipoprotein B. Similar results were found for differences in carotid intima-medial thickness and ankle-brachial index. Metabolic syndrome was identified in 65% of FCHL and 71% of FHTG patients compared with 19% in controls without FCHL or FHTG and was associated with an odds ratio of 3.3 (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000081777.17879.85