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Effect of membrane fatty acid composition on the action of thyroid hormones on (Ca2+ + Mg2+)-adenosine triphosphatase from rat erythrocyte
The action of L-triiodothyronine, L-thyroxine, and their analogues on the (Ca2+ + Mg2+)-ATPase of erythrocytes from rats fed with two different fat-supplemented diets has been studied. It was found that only L-triiodothyronine and L-thyroxine have effects on the (Ca2+ + Mg2+)-ATPase of both groups,...
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Published in: | The Journal of biological chemistry 1981-07, Vol.256 (14), p.7113-7114 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The action of L-triiodothyronine, L-thyroxine, and their analogues on the (Ca2+ + Mg2+)-ATPase of erythrocytes from rats fed
with two different fat-supplemented diets has been studied. It was found that only L-triiodothyronine and L-thyroxine have
effects on the (Ca2+ + Mg2+)-ATPase of both groups, producing inhibition in rats fed with corn oil and activation in rats
fed with lard-supplemented diets. The half-maximal effect for L-triiodothyronine and L-thyroxine are, respectively, on the
order of 10(-10) and 10(-8) M. These changes were not obtained with analogues of the hormones. It is suggested that the response
of this enzymatic system to the hormonal action is conditioned by the fatty acid composition of membrane-bound lipids. This
observation is novel in the hormonal research area. |
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ISSN: | 0021-9258 1083-351X |
DOI: | 10.1016/s0021-9258(19)68932-5 |