Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme

The bioassay‐guided fractionation of the n‐BuOH extract of Abeliophyllum distichum afforded acteoside (1), isoacteoside (2), rutin (3), and hirsutrin (4). Compounds 1–3 moderately inhibited the angiotensin I converting enzyme activity in a dose‐dependent manner. Compounds 1–3 showed the 50% inhibito...

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Published in:Phytotherapy research 2003-08, Vol.17 (7), p.811-813
Main Authors: Oh, Hyuncheol, Kang, Dae-Gill, Kwon, Tae-Oh, Jang, Kyu Kwan, Chai, Kyu-Yun, Yun, Young-Gab, Chung, Hun-Taeg, Lee, Ho-Sub
Format: Article
Language:English
Subjects:
Abeliophyllum distichum
Angiotensin converting enzyme
Angiotensin-Converting Enzyme Inhibitors - administration & dosage
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Animals
Antihypertensive
Biological and medical sciences
Dose-Response Relationship, Drug
General pharmacology
Glucosides - pharmacology
Glycosides
Glycosides - administration & dosage
Glycosides - pharmacology
Glycosides - therapeutic use
Medical sciences
Oleaceae
Peptidyl-Dipeptidase A - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - pharmacology
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Rats
Rutin - pharmacology
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Summary:The bioassay‐guided fractionation of the n‐BuOH extract of Abeliophyllum distichum afforded acteoside (1), isoacteoside (2), rutin (3), and hirsutrin (4). Compounds 1–3 moderately inhibited the angiotensin I converting enzyme activity in a dose‐dependent manner. Compounds 1–3 showed the 50% inhibitory concentration values of 228 µg/mL, 290 µg/mL, and 278 µg/mL, respectively. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1199