DNA dynamics in a microchannel

An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby s...

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Bibliographic Details
Published in:Physical review letters 2003-07, Vol.91 (3), p.038102-038102, Article 038102
Main Authors: Jendrejack, Richard M, Dimalanta, Eileen T, Schwartz, David C, Graham, Michael D, de Pablo, Juan J
Format: Article
Language:English
Subjects:
Computer Simulation
DNA - chemistry
Kinetics
Models, Chemical
Stochastic Processes
Viscosity
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Summary:An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby segregate according to molecular weight. Capturing these effects requires the detailed incorporation of solvent flow in the simulation method, demonstrating the importance of hydrodynamic effects in the dynamics of confined macromolecules.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.91.038102