Plasma oxidative parameters and mortality in patients with severe burn injury

To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury. Prospective, comparative observational study in an intensive care unit, burn...

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Bibliographic Details
Published in:Intensive care medicine 2003-08, Vol.29 (8), p.1380-1383
Main Authors: Ritter, Cristiane, Andrades, Michael, Guerreiro, Márcio, Zavaschi, Leonardo, Gelain, Daniel Pens, Souza, Luis Fernando, Ribeiro, Cyntia A, Clausell, Nadine, Menna-Barreto, Sérgio, Moreira, José Cláudio F, Dal-Pizzol, Felipe
Format: Article
Language:English
Subjects:
Acids
Adult
Antioxidants
Biomarkers
Blood Proteins - metabolism
Burns
Burns - blood
Burns - mortality
Critical Care
Female
Humans
Intensive care
Lipid Peroxidation
Lipids
Male
Mortality
Oxidation-Reduction
Oxidative stress
Plasma
Prognosis
Prospective Studies
Proteins
Superoxide Dismutase - blood
Thiobarbiturates - blood
Trauma
Xanthine Oxidase - blood
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Summary:To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury. Prospective, comparative observational study in an intensive care unit, burn division, in a trauma hospital. Twenty-five consecutive patients who met the established criteria for severe burn injury (total burn surface area of more than 30%). Plasma thiobarbituric acid reactive species and protein carbonyls levels were significantly higher in nonsurvivors than in survivors at 0 and 6 h. Elevated xanthine oxidase activity at 0 h was associated with adverse outcome after burn injury. In contrast, plasma superoxide dismutase activity and total radical-trapping antioxidant parameter did not differ significantly between nonsurvivors and survivors at any time point. For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-003-1833-9