Preparation and Antidiabetic Activity of New 3-Methyl-5-phenylpyrazolesulfonylurea Derivatives

Two series of p-(3-methyl-5-phenylpyrazole-1)benzene-sulfonylurea and p-(4-bromo-3-methyl-5-phenylpyrazole-1)benzene-sulfonylurea derivatives were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent antidiabetic activity.

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1981-06, Vol.70 (6), p.602-605
Main Authors: Soliman, Raafat, Feid-Allah, Hassan M.
Format: Article
Language:English
Subjects:
3-Methyl-5-phenylpyrazolesulfonylurea derivatives-preparation and evaluation for antidiabetic activity
Animals
Antidiabetic activity-3-methyl-5-phenylpyra-zolesulfonylurea derivatives synthesized and tested
Blood Glucose - metabolism
Diabetes Mellitus, Experimental - drug therapy
Hypoglycemic Agents - chemical synthesis
Male
Mice
Pyrazoles - chemical synthesis
Pyrazoles - pharmacology
Structure-activity relationships-3-methyl-5-phenylpyrazolesulfonylurea derivatives and antidiabetic activity
Sulfonylurea Compounds - chemical synthesis
Sulfonylurea Compounds - pharmacology
Thiourea - analogs & derivatives
Thiourea - chemical synthesis
Thiourea - pharmacology
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Description
Summary:Two series of p-(3-methyl-5-phenylpyrazole-1)benzene-sulfonylurea and p-(4-bromo-3-methyl-5-phenylpyrazole-1)benzene-sulfonylurea derivatives were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent antidiabetic activity.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600700607