Sequence space localization in the immune system response to vaccination and disease

We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can increase susceptibility to future exposures to the same disease, is explained as...

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Bibliographic Details
Published in:Physical review letters 2003-08, Vol.91 (6), p.068101-068101, Article 068101
Main Authors: Deem, Michael W, Lee, Ha Youn
Format: Article
Language:English
Subjects:
Animals
Antibodies - genetics
Antibodies - immunology
Antigens - genetics
Antigens - immunology
B-Lymphocytes - immunology
Evolution, Molecular
Humans
Immunologic Memory
Influenza Vaccines - immunology
Influenza, Human - immunology
Kinetics
Models, Immunological
Orthomyxoviridae - immunology
Thermodynamics
Viral Proteins - immunology
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Summary:We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can increase susceptibility to future exposures to the same disease, is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.91.068101