Empty follicle syndrome in two sisters with three cycles: Case report

Empty follicle syndrome (EFS) is characterized by a lack of retrieved oocytes in the presence of multiple follicle development, in both natural and stimulated cycles. The aim of the present case report is to point out the possibility of genetic factors that could be responsible for some occurrences...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2003-09, Vol.18 (9), p.1864-1867
Main Authors: Önalan, Gögsen, Pabuçcu, Recai, Önalan, Reside, Ceylaner, Serdar, Selam, Belgin
Format: Article
Language:English
Subjects:
Adult
Chorionic Gonadotropin - therapeutic use
Female
Fertilization in Vitro
Hearing Loss, Sensorineural - genetics
Humans
Key words: cyclic AMP/empty follicle syndrome/ICSI/IVF
Oocytes
Ovarian Diseases - genetics
Ovarian Diseases - physiopathology
Ovarian Follicle
Retreatment
Salvage Therapy
Sperm Injections, Intracytoplasmic
Syndrome
Tissue and Organ Harvesting
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Summary:Empty follicle syndrome (EFS) is characterized by a lack of retrieved oocytes in the presence of multiple follicle development, in both natural and stimulated cycles. The aim of the present case report is to point out the possibility of genetic factors that could be responsible for some occurrences of EFS. Two sisters with moderate deafness underwent controlled ovarian hyperstimulation and IVF/ICSI cycles at the same centre. During all three cycles there were normal follicular development, estradiol levels and bio‐available hCG plasma levels, but no oocytes and cumulus–corona complexes were retrieved, despite second hCG injections. These cases may represent an inherited condition of EFS with hearing loss with genetic factors affecting both the aetiology of EFS and the hearing loss.
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/deg371