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DNA damage in digestive gland and mantle tissue of the mussel Perna perna
Data concerning the susceptibility of DNA to damage by reactive oxygen and nitrogen species and other endogenous compounds produced by physiological stress in marine organisms is lacking, especially in bivalve mollusks. In this article, we analyzed the background levels of lipid peroxidation (malond...
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| Published in: | Comparative biochemistry and physiology. Toxicology & pharmacology 2003-07, Vol.135 (3), p.295-303 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c392t-f841307f4ac767d5ff2848eff8a99a3037697fd3cb939bb6fe3994aa43819ced3 |
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| cites | cdi_FETCH-LOGICAL-c392t-f841307f4ac767d5ff2848eff8a99a3037697fd3cb939bb6fe3994aa43819ced3 |
| container_end_page | 303 |
| container_issue | 3 |
| container_start_page | 295 |
| container_title | Comparative biochemistry and physiology. Toxicology & pharmacology |
| container_volume | 135 |
| creator | de Almeida, Eduardo Alves de Almeida Marques, Sabrina Klitzke, Clécio Fernando Bainy, Afonso Celso Dias de Medeiros, Marisa Helena Gennari Di Mascio, Paolo de Melo Loureiro, Ana Paula |
| description | Data concerning the susceptibility of DNA to damage by reactive oxygen and nitrogen species and other endogenous compounds produced by physiological stress in marine organisms is lacking, especially in bivalve mollusks. In this article, we analyzed the background levels of lipid peroxidation (malondialdehyde, MDA), 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and 1,
N
2-etheno-2′-deoxyguanosine (1,
N
2-εdGuo) in digestive gland and mantle tissue of mussels
Perna perna collected at a cultivation zone in Florianópolis (Santa Catarina, Brazil). The present data point to the possibility of the use of both 8-oxodGuo and 1,
N
2-εdGuo as complementary indicators of oxidative stress processes in mussels. A sensitive method coupling high performance liquid chromatography to mass spectrometry was applied for the detection of 1,
N
2-εdGuo in mussel tissues. |
| doi_str_mv | 10.1016/S1532-0456(03)00117-0 |
| format | article |
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N
2-etheno-2′-deoxyguanosine (1,
N
2-εdGuo) in digestive gland and mantle tissue of mussels
Perna perna collected at a cultivation zone in Florianópolis (Santa Catarina, Brazil). The present data point to the possibility of the use of both 8-oxodGuo and 1,
N
2-εdGuo as complementary indicators of oxidative stress processes in mussels. A sensitive method coupling high performance liquid chromatography to mass spectrometry was applied for the detection of 1,
N
2-εdGuo in mussel tissues.</description><identifier>ISSN: 1532-0456</identifier><identifier>EISSN: 1878-1659</identifier><identifier>DOI: 10.1016/S1532-0456(03)00117-0</identifier><identifier>PMID: 12927904</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>8-oxodGuo ; Animals ; Bivalvia ; Bivalvia - chemistry ; Bivalvia - metabolism ; DNA damage ; DNA Damage - physiology ; Etheno adduct ; Gastrointestinal Tract - chemistry ; Gastrointestinal Tract - metabolism ; HPLC ; Lipid peroxidation ; Marine ; Mass spectrometry ; Mussel ; Oxidative stress ; Oxidative Stress - physiology ; Perna perna ; Reactive Oxygen Species - analysis ; Reactive Oxygen Species - metabolism</subject><ispartof>Comparative biochemistry and physiology. Toxicology & pharmacology, 2003-07, Vol.135 (3), p.295-303</ispartof><rights>2003 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-f841307f4ac767d5ff2848eff8a99a3037697fd3cb939bb6fe3994aa43819ced3</citedby><cites>FETCH-LOGICAL-c392t-f841307f4ac767d5ff2848eff8a99a3037697fd3cb939bb6fe3994aa43819ced3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12927904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Almeida, Eduardo Alves</creatorcontrib><creatorcontrib>de Almeida Marques, Sabrina</creatorcontrib><creatorcontrib>Klitzke, Clécio Fernando</creatorcontrib><creatorcontrib>Bainy, Afonso Celso Dias</creatorcontrib><creatorcontrib>de Medeiros, Marisa Helena Gennari</creatorcontrib><creatorcontrib>Di Mascio, Paolo</creatorcontrib><creatorcontrib>de Melo Loureiro, Ana Paula</creatorcontrib><title>DNA damage in digestive gland and mantle tissue of the mussel Perna perna</title><title>Comparative biochemistry and physiology. Toxicology & pharmacology</title><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><description>Data concerning the susceptibility of DNA to damage by reactive oxygen and nitrogen species and other endogenous compounds produced by physiological stress in marine organisms is lacking, especially in bivalve mollusks. In this article, we analyzed the background levels of lipid peroxidation (malondialdehyde, MDA), 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and 1,
N
2-etheno-2′-deoxyguanosine (1,
N
2-εdGuo) in digestive gland and mantle tissue of mussels
Perna perna collected at a cultivation zone in Florianópolis (Santa Catarina, Brazil). The present data point to the possibility of the use of both 8-oxodGuo and 1,
N
2-εdGuo as complementary indicators of oxidative stress processes in mussels. A sensitive method coupling high performance liquid chromatography to mass spectrometry was applied for the detection of 1,
N
2-εdGuo in mussel tissues.</description><subject>8-oxodGuo</subject><subject>Animals</subject><subject>Bivalvia</subject><subject>Bivalvia - chemistry</subject><subject>Bivalvia - metabolism</subject><subject>DNA damage</subject><subject>DNA Damage - physiology</subject><subject>Etheno adduct</subject><subject>Gastrointestinal Tract - chemistry</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>HPLC</subject><subject>Lipid peroxidation</subject><subject>Marine</subject><subject>Mass spectrometry</subject><subject>Mussel</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Perna perna</subject><subject>Reactive Oxygen Species - analysis</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>1532-0456</issn><issn>1878-1659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EoqXwCSCvECwCdpzE9gpV5VWpAiRgbTnxuBjlUeKkEn-P0xaxZOHxLI59Zw5Cp5RcUUKz61easjgiSZpdEHZJCKU8IntoTAUXEc1SuR_6X2SEjrz_JISkCc0O0YjGMuaSJGM0v32aYqMrvQTsamzcEnzn1oCXpa4NHk6l664E3Dnve8CNxd0H4Kr3Hkr8Am2t8Wqox-jA6tLDye6eoPf7u7fZY7R4fpjPpouoYDLuIisSygi3iS54xk1qbSwSAdYKLaVmhPFMcmtYkUsm8zyzwKRMtE6YoLIAwybofPvvqm2--jCtqpwvoAzzQtN7xVnKWRaLf0EqhZAhMIDpFizaxvsWrFq1rtLtt6JEDbLVRrYaTCrC1EZ2aCbobBfQ5xWYv1c7uwG42QIQfKwdtMoXDuqwhWuh6JRp3D8RP2yqjUo</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>de Almeida, Eduardo Alves</creator><creator>de Almeida Marques, Sabrina</creator><creator>Klitzke, Clécio Fernando</creator><creator>Bainy, Afonso Celso Dias</creator><creator>de Medeiros, Marisa Helena Gennari</creator><creator>Di Mascio, Paolo</creator><creator>de Melo Loureiro, Ana Paula</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TN</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>DNA damage in digestive gland and mantle tissue of the mussel Perna perna</title><author>de Almeida, Eduardo Alves ; de Almeida Marques, Sabrina ; Klitzke, Clécio Fernando ; Bainy, Afonso Celso Dias ; de Medeiros, Marisa Helena Gennari ; Di Mascio, Paolo ; de Melo Loureiro, Ana Paula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-f841307f4ac767d5ff2848eff8a99a3037697fd3cb939bb6fe3994aa43819ced3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>8-oxodGuo</topic><topic>Animals</topic><topic>Bivalvia</topic><topic>Bivalvia - chemistry</topic><topic>Bivalvia - metabolism</topic><topic>DNA damage</topic><topic>DNA Damage - physiology</topic><topic>Etheno adduct</topic><topic>Gastrointestinal Tract - chemistry</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>HPLC</topic><topic>Lipid peroxidation</topic><topic>Marine</topic><topic>Mass spectrometry</topic><topic>Mussel</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Perna perna</topic><topic>Reactive Oxygen Species - analysis</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Almeida, Eduardo Alves</creatorcontrib><creatorcontrib>de Almeida Marques, Sabrina</creatorcontrib><creatorcontrib>Klitzke, Clécio Fernando</creatorcontrib><creatorcontrib>Bainy, Afonso Celso Dias</creatorcontrib><creatorcontrib>de Medeiros, Marisa Helena Gennari</creatorcontrib><creatorcontrib>Di Mascio, Paolo</creatorcontrib><creatorcontrib>de Melo Loureiro, Ana Paula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oceanic Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. 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Toxicology & pharmacology</jtitle><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>135</volume><issue>3</issue><spage>295</spage><epage>303</epage><pages>295-303</pages><issn>1532-0456</issn><eissn>1878-1659</eissn><abstract>Data concerning the susceptibility of DNA to damage by reactive oxygen and nitrogen species and other endogenous compounds produced by physiological stress in marine organisms is lacking, especially in bivalve mollusks. In this article, we analyzed the background levels of lipid peroxidation (malondialdehyde, MDA), 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and 1,
N
2-etheno-2′-deoxyguanosine (1,
N
2-εdGuo) in digestive gland and mantle tissue of mussels
Perna perna collected at a cultivation zone in Florianópolis (Santa Catarina, Brazil). The present data point to the possibility of the use of both 8-oxodGuo and 1,
N
2-εdGuo as complementary indicators of oxidative stress processes in mussels. A sensitive method coupling high performance liquid chromatography to mass spectrometry was applied for the detection of 1,
N
2-εdGuo in mussel tissues.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12927904</pmid><doi>10.1016/S1532-0456(03)00117-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1532-0456 |
| ispartof | Comparative biochemistry and physiology. Toxicology & pharmacology, 2003-07, Vol.135 (3), p.295-303 |
| issn | 1532-0456 1878-1659 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73573628 |
| source | ScienceDirect Freedom Collection |
| subjects | 8-oxodGuo Animals Bivalvia Bivalvia - chemistry Bivalvia - metabolism DNA damage DNA Damage - physiology Etheno adduct Gastrointestinal Tract - chemistry Gastrointestinal Tract - metabolism HPLC Lipid peroxidation Marine Mass spectrometry Mussel Oxidative stress Oxidative Stress - physiology Perna perna Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism |
| title | DNA damage in digestive gland and mantle tissue of the mussel Perna perna |
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