Vaccinia virus transcription

Department of Biochemistry, Purdue University, West Lafayette, IN 47907-1153, USA Correspondence Steven Broyles broyles{at}purdue.edu Vaccinia virus replication takes place in the cytoplasm of the host cell. The nearly 200 kbp genome owes part of its complexity to encoding most of the proteins invol...

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Bibliographic Details
Published in:Journal of general virology 2003-09, Vol.84 (9), p.2293-2303
Main Author: Broyles, Steven S
Format: Article
Language:English
Subjects:
DNA-Directed RNA Polymerases - genetics
Gene Expression Regulation
Transcription Factors
Transcription, Genetic
Vaccinia virus
Vaccinia virus - genetics
Viral Proteins - genetics
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Summary:Department of Biochemistry, Purdue University, West Lafayette, IN 47907-1153, USA Correspondence Steven Broyles broyles{at}purdue.edu Vaccinia virus replication takes place in the cytoplasm of the host cell. The nearly 200 kbp genome owes part of its complexity to encoding most of the proteins involved in genome and mRNA synthesis. The multisubunit vaccinia virus RNA polymerase requires a separate set of virus-encoded proteins for the transcription of the early, intermediate and late classes of genes. Cell fractionation studies have provided evidence for a role for host cell proteins in the initiation and termination of vaccinia virus intermediate and late gene transcription. Vaccinia virus resembles nuclear DNA viruses in the integration of viral and host proteins for viral mRNA synthesis, yet is markedly less reliant on host proteins than its nuclear counterparts. Published ahead of print on 28 May 2003 as DOI 10.1099/vir.0.18942-0
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.18942-0