Unexpected Relationship between Plasma Homocysteine and Intrauterine Growth Restriction

Moderate hyperhomocysteinemia is considered a risk factor for thrombosis and atherosclerosis. We hypothesized that higher maternal and newborn homocysteine concentrations in plasma would increase the risk of intrauterine growth restriction through placental thrombosis. We carried out a case-control...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2003-09, Vol.49 (9), p.1476-1482
Main Authors: Infante-Rivard, Claire, Rivard, Georges-Etienne, Gauthier, Robert, Theoret, Yves
Format: Article
Language:English
Subjects:
Atherosclerosis
Biological and medical sciences
Birth weight
Case-Control Studies
Confidence intervals
Diseases of mother, fetus and pregnancy
Female
Fetal Blood
Fetal Growth Retardation - blood
Fetal Growth Retardation - diagnosis
Gestational Age
Gynecology. Andrology. Obstetrics
Homocysteine
Homocysteine - blood
Humans
Infant, Low Birth Weight
Infant, Newborn
Male
Medical sciences
Methylenetetrahydrofolate Reductase (NADPH2)
Mothers
Oxidoreductases Acting on CH-NH Group Donors - genetics
Plasma
Polymorphism, Genetic
Pregnancy
Pregnancy. Fetus. Placenta
Risk factors
Thromboembolism
Thrombosis
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Summary:Moderate hyperhomocysteinemia is considered a risk factor for thrombosis and atherosclerosis. We hypothesized that higher maternal and newborn homocysteine concentrations in plasma would increase the risk of intrauterine growth restriction through placental thrombosis. We carried out a case-control study that included all cases born at our institution over a 2-year period whose birthweight was below the 10th percentiles for gestational age and sex according to Canadian norms; controls were born at the same period and institution at or above the 10th percentiles and were matched on gestational age, race, and sex. Homocysteine was measured in cord and maternal blood. The analysis included 483 case and 468 control mothers and 409 case and 438 control newborns. Homocysteine values were largely
ISSN:0009-9147
1530-8561
DOI:10.1373/49.9.1476