Long-term sertraline treatment and peripheral biochemical markers in female depressed patients

Serotonergic system is implicated in the pathogenesis of depression. Peripheral biochemical markers, platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were determined spectrofluorimetrically at baseline and after 4 and 24 weeks of sertraline (a selective serotonin reuptake inhi...

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Published in:Progress in neuro-psychopharmacology & biological psychiatry 2003-08, Vol.27 (5), p.759-765
Main Authors: Pivac, Nela, Mück-Šeler, Dorotea, Šagud, Marina, Jakovljević, Miro, Mustapić, Maja, Mihaljević-Peleš, Alma
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Biomarkers - blood
Blood platelets
Chi-Square Distribution
Depressive Disorder, Major - blood
Depressive Disorder, Major - drug therapy
Female
Humans
Major depression
Middle Aged
Monoamine oxidase
Monoamine Oxidase - blood
Remission
Response and nonresponse
Serotonin
Serotonin - blood
Sertraline
Sertraline - administration & dosage
Treatment Outcome
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Summary:Serotonergic system is implicated in the pathogenesis of depression. Peripheral biochemical markers, platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were determined spectrofluorimetrically at baseline and after 4 and 24 weeks of sertraline (a selective serotonin reuptake inhibitor (SSRI)) treatment in 15 female nonsuicidal, nonpsychotic patients with major depression and compared with 15 drug-free healthy women. The aim of the study was to determine the effects of 4 and 24 weeks of sertraline treatment on platelet 5-HT concentration and platelet MAO activity in depressed patients subdivided according to the treatment response into remitters, responders and nonresponders after 4 and 24 weeks of sertraline treatment based on the 70%, 50–69% and
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(03)00105-2