Tissue Molecular Anatomy Project (TMAP): An expression database for comparative cancer proteomics

By mining publicly accessible databases, we have developed a collection of tissue‐specific predictive protein expression maps as a function of cancer histological state. Data analysis is applied to the differential expression of gene products in pooled libraries from the normal to the altered state(...

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Bibliographic Details
Published in:Proteomics (Weinheim) 2003-08, Vol.3 (8), p.1445-1453
Main Authors: Medjahed, Djamel, Luke, Brian T., Tontesh, Tawady S., Smythers, Gary W., Munroe, David J., Lemkin, Peter F.
Format: Article
Language:English
Subjects:
Databases, Protein
Expressed Sequence Tags
Neoplasms - metabolism
Protein expression map
Proteomics
Tissue Molecular Anatomy Project
Two-dimensional gel electrophoresis
VIRTUAL2D
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Summary:By mining publicly accessible databases, we have developed a collection of tissue‐specific predictive protein expression maps as a function of cancer histological state. Data analysis is applied to the differential expression of gene products in pooled libraries from the normal to the altered state(s). We wish to report the initial results of our survey across different tissues and explore the extent to which this comparative approach may help uncover panels of potential biomarkers of tumorigenesis which would warrant further examination in the laboratory.
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.200300488