Phylogenetic Origin and Virulence Genotype in Relation to Resistance to Fluoroquinolones and/or Extended-Spectrum Cephalosporins and Cephamycins among Escherichia coli Isolates from Animals and Humans

In Escherichia coli infection, the implications of fluoroquinolone (FQ) and extended-spectrum cephalosporin plus cephamycin (AmpC) resistance for phylogenetic origin and virulence potential are undefined, as is the influence of ecological context on these associations. Accordingly, 106 E. coli isola...

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Bibliographic Details
Published in:The Journal of infectious diseases 2003-09, Vol.188 (5), p.759-768
Main Authors: Johnson, James R., Kuskowski, Michael A., Owens, Krista, Gajewski, Abby, Winokur, Patricia L.
Format: Article
Language:English
Subjects:
AmpC protein
Animals
Anti-Infective Agents - pharmacology
Bacterial Proteins
beta-Lactamases - genetics
Cattle
Cephalosporin Resistance
Cephalosporins - pharmacology
Cephamycins - pharmacology
Drug Resistance, Bacterial
Escherichia coli
Escherichia coli - classification
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - pathogenicity
Escherichia coli Infections - microbiology
Fluoroquinolones
Genotype
Humans
Microbial Sensitivity Tests
Phylogeny
Random Amplified Polymorphic DNA Technique
Serotyping
Swine
Virulence - genetics
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Summary:In Escherichia coli infection, the implications of fluoroquinolone (FQ) and extended-spectrum cephalosporin plus cephamycin (AmpC) resistance for phylogenetic origin and virulence potential are undefined, as is the influence of ecological context on these associations. Accordingly, 106 E. coli isolates exhibiting FQ and/or AmpC resistance and 98 susceptible isolates were compared with regard to phylogenetic background and virulence profiles, stratified by host group (104 predominantly extraintestinal human isolates and 100 predominantly intestinal cattle and swine isolates). Although resistant isolates exhibited significant shifts in phylogenetic distribution and virulence profiles, human and animal isolates exhibited different phylogenetic shifts, and only among human isolates did resistance predict reduced virulence. Evidence for similar strains being resistant versus susceptible was scant. The O15:K52:H1 clonal group and the closely related “clonal group A” featured prominently among resistant and susceptible human isolates, respectively. Thus, in E. coli antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion
ISSN:0022-1899
1537-6613
DOI:10.1086/377455