Clonal analysis of bilateral mammary carcinomas by clinical evaluation and partial allelotyping

Bilateral breast carcinomas may represent contralateral metastases or new primary tumors. The presence of carcinoma in situ, a lower grade, or a different histotype in the second tumor is considered a clinical criterion for a second primary tumor. In this study, 26 bilateral breast carcinomas from 1...

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Bibliographic Details
Published in:American journal of clinical pathology 2003-08, Vol.120 (2), p.168-174
Main Authors: TSE, Gary M. K, KUNG, Fred Y. L, CHAN, Amy B. W, LAW, Bonita K. B, CHANG, Alexander R, LO, Kwok-Wai
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Biomarkers - analysis
Breast Neoplasms - chemistry
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma in Situ - chemistry
Carcinoma in Situ - genetics
Carcinoma in Situ - pathology
Clone Cells
DNA, Neoplasm - analysis
Female
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Loss of Heterozygosity
Mammary gland diseases
Medical sciences
Microsatellite Repeats
Middle Aged
Neoplasms, Multiple Primary - chemistry
Neoplasms, Multiple Primary - genetics
Neoplasms, Second Primary - chemistry
Neoplasms, Second Primary - genetics
Polymerase Chain Reaction
Reproducibility of Results
Tumors
Citations: Items that cite this one
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Description
Summary:Bilateral breast carcinomas may represent contralateral metastases or new primary tumors. The presence of carcinoma in situ, a lower grade, or a different histotype in the second tumor is considered a clinical criterion for a second primary tumor. In this study, 26 bilateral breast carcinomas from 13 patients were analyzed based on clinical criteria, and the results were compared with those obtained by partial allelotyping using 47 markers at 7 chromosomal arms. Of the 8 synchronous tumors, 5 were concluded to be distinct primary tumors using clinical criteria; some were confirmed by partial allelotyping. In the remaining 3 cases, partial allelotyping showed distinct primary tumors. Five patients had metachronous carcinomas with 3 distinct primary tumors, 1 metastasis, and 1 that was uncertain by clinical criteria. Three cases were confirmed by partial allelotyping, and the uncertain case was shown to be distinct primary tumors. No discrepant results were noted. Stringent application of clinical criteria is accurate for differentiating second primary tumors from metastases.
ISSN:0002-9173
1943-7722
DOI:10.1309/6YEPMCHACPG2BD15