Effect of increased (99m)Tc/(99)Tc ratios on count rates in sentinel node procedures: a randomised study

The aim of this study was to evaluate the count rates of sentinel lymph nodes (SLNs) in patients with breast cancer in the operating theatre, using (99m)Tc-Nanocoll with different ratios of technetium-99m to technetium-99. After written informed consent had been obtained, we tested different ratios...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2003-09, Vol.30 (9), p.1231-1235
Main Authors: Gommans, G M M, van der Zant, F M, van der Schors, T G, van Dongen, A, Teule, G J J, Clarijs, W W J, Langenhorst, B L A M, de Waard, J W D
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - diagnostic imaging
Diagnostic Errors
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Image Enhancement - methods
Injections - methods
Lymph Nodes - diagnostic imaging
Lymphatic Metastasis
Middle Aged
Radiometry - methods
Radionuclide Imaging
Radiopharmaceuticals - administration & dosage
Reproducibility of Results
Sensitivity and Specificity
Sentinel Lymph Node Biopsy - methods
Technetium Tc 99m Aggregated Albumin - administration & dosage
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Summary:The aim of this study was to evaluate the count rates of sentinel lymph nodes (SLNs) in patients with breast cancer in the operating theatre, using (99m)Tc-Nanocoll with different ratios of technetium-99m to technetium-99. After written informed consent had been obtained, we tested different ratios of (99m)Tc/(99)Tc-Nanocoll in a double-blinded randomised study performed in 161 patients. Twenty-five MBq/ microg (99m)Tc-colloid albumin was prepared in vacuum. In 87 patients (group A) a 2-h elution was used and in 74 patients (group B) a 24-h elution was used. Patients were subcategorised into subgroups 1 and 3, in which an SLN procedure for breast carcinoma was performed simultaneously with lumpectomy, and subgroups 2 and 4, in which an SLN procedure was performed 2-3 weeks after prior excision biopsy. All patients were injected along the lateral border of the areola (two injections: 50 MBq/0.3 ml intradermally and 50 MBq/2 ml intraparenchymally). Ex vivo measurement of count rates was performed with a gamma probe. Comparing groups A and B in respect of registered counts per second (cps) of excised SLNs, a significant difference was found ( P
ISSN:1619-7070
DOI:10.1007/s00259-003-1227-9