Determination of pKa values of organic bases in aqueous acetonitrile solutions using capillary electrophoresis

Capillary electrophoresis (CE) was used for the determination of ionisation constants (pKa) of a variety of organic bases in aqueous acetonitrile solutions over the range 0-60% (v/v) acetonitrile. These bases are used as test compounds in HPLC column evaluation, thus knowledge of their pKa in hydro-...

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Bibliographic Details
Published in:Journal of Chromatography A 2003-07, Vol.1004 (1-2), p.71-79
Main Authors: Buckenmaier, Stephan M C, McCalley, David V, Euerby, Melvin R
Format: Article
Language:English
Subjects:
Acetonitriles - chemistry
Buffers
Electrophoresis, Capillary - methods
Hydrogen-Ion Concentration
Organic Chemicals - chemistry
Water - chemistry
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Summary:Capillary electrophoresis (CE) was used for the determination of ionisation constants (pKa) of a variety of organic bases in aqueous acetonitrile solutions over the range 0-60% (v/v) acetonitrile. These bases are used as test compounds in HPLC column evaluation, thus knowledge of their pKa in hydro-organic solutions is useful. The base pKa decreased with acetonitrile concentration and significant shifts from the aqueous pKa (up to -0.8) were found using 60% acetonitrile. The CE application was confirmed to be very suitable for fast and accurate pKa measurement in aqueous organic solutions.
ISSN:0021-9673
DOI:10.1016/s0021-9673(03)00717-9