Diabetes Mellitus Adversely Affects the Outcomes of Thrombolytic Therapy in Patients with Acute Myocardial Infarction

This study was performed to evaluate whether coexistent diabetes mellitus has any adverse effect on the outcomes of thrombolytic therapy in patients with acute myocardial infarction. Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarct...

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Bibliographic Details
Published in:Angiology 2003-07, Vol.54 (4), p.449-456
Main Authors: Tikiz, Hakan, Tezcan, Ugur, Ileri, Mehmet, Balbay, Yücel, Atak, Ramazan, Kütük, Emine
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cardiomyopathies - complications
Cardiomyopathies - drug therapy
Cardiomyopathies - physiopathology
Care and treatment
Collateral Circulation - physiology
Complications and side effects
Coronary Angiography
Coronary Disease - diagnostic imaging
Diabetes
Diabetes Complications
Diabetes Mellitus - physiopathology
Electrocardiography
Female
Fibrinolytic Agents - therapeutic use
Heart attack
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Streptokinase - therapeutic use
Thrombolytic Therapy
Tissue Plasminogen Activator - therapeutic use
Ventricular Function, Left - physiology
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Summary:This study was performed to evaluate whether coexistent diabetes mellitus has any adverse effect on the outcomes of thrombolytic therapy in patients with acute myocardial infarction. Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarction with and without diabetes mellitus (42% vs 45.4%, p > 0.05), the results of late angiographic examination showed a significantly lower rate of patency in infarct- related coronary artery (defined as TIMI 3 flow) in diabetics compared to nondiabetics (28.9% vs 41.3%, p< 0.001). The global left ventricular function was also poorer in diabetics (left ventricular wall motion score was 18.6 ±7.3 in diabetics and 14.1 ±4.6 in nondiabetics, p < 0.01 1).
ISSN:0003-3197
1940-1574
DOI:10.1177/000331970305400409