Nuclear mRNA export: insights from virology

To maximize the production of progeny virions, several viruses have evolved mechanisms that promote the selective nuclear export of viral mRNA transcripts while, in some cases, inhibiting the export of cellular mRNAs. To achieve this goal, viruses have evolved regulatory proteins and cis-acting RNA...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2003-08, Vol.28 (8), p.419-424
Main Author: Cullen, Bryan R
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Animals
Cell Nucleus - metabolism
Gene Products, rev - metabolism
HIV-1 - physiology
Models, Biological
rev Gene Products, Human Immunodeficiency Virus
RNA, Messenger - metabolism
RNA, Viral
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Summary:To maximize the production of progeny virions, several viruses have evolved mechanisms that promote the selective nuclear export of viral mRNA transcripts while, in some cases, inhibiting the export of cellular mRNAs. To achieve this goal, viruses have evolved regulatory proteins and cis-acting RNA elements that selectively interact with key cellular nuclear export factors. Efforts to identify the cellular targets of these viral proteins and RNA elements have led to the identification of Crm1 and Tap as essential human nuclear RNA-export factors and continue to provide insights into how mRNAs are selected for export
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(03)00142-7