Temporal Lobe Epilepsy as a Unique Manifestation of Multiple Sclerosis

To report on five patients with temporal lobe epilepsy (TLE) as the unique manifestation of multiple sclerosis (MS). Among 350 consecutive MS patients, we identified 16/350 (4.6%) who also had epileptic seizures. Here, we review their electrophysiological and clinical features. Five of these 16 pati...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 2003-08, Vol.30 (3), p.228-232
Main Authors: Gambardella, Antonio, Valentino, Paola, Labate, Angelo, Sibilia, Grazia, Ruscica, Francesca, Colosimo, Eleonora, Nisticò, Rita, Messina, Demetrio, Zappia, Mario, Quattrone, Aldo
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - therapeutic use
Biological and medical sciences
Brain - pathology
Brain - physiopathology
Electroencephalography
Epilepsy, Temporal Lobe - diagnosis
Epilepsy, Temporal Lobe - drug therapy
Epilepsy, Temporal Lobe - etiology
Epilepsy, Temporal Lobe - physiopathology
Female
Follow-Up Studies
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system (semeiology, syndromes)
Neurology
Severity of Illness Index
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Summary:To report on five patients with temporal lobe epilepsy (TLE) as the unique manifestation of multiple sclerosis (MS). Among 350 consecutive MS patients, we identified 16/350 (4.6%) who also had epileptic seizures. Here, we review their electrophysiological and clinical features. Five of these 16 patients (four female, one male; mean age 34.2 years; range 31 to 38) with MS and epileptic seizures had an extremely homogeneous clinical picture characterized by TLE as the unique manifestation of MS, even at long follow-up (mean: five years; range 4 to 10). In all patients, seizures started in the second or third decade. Brain MRI revealed at least one juxta-cortical lesion within the temporal region. Antiepileptic medication was always effective. The present study provides the first evidence of a peculiar form of MS characterized by TLE as the unique manifestation of the disease with no disability or MS relapses at long-term follow-up.
ISSN:0317-1671
2057-0155
DOI:10.1017/S031716710000264X