Human T Cell Surface Antigens Bearing a Structural Relationship to HLA Antigens

Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is asso...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1981-06, Vol.78 (6), p.3858-3862
Main Authors: Cotner, Tom, Mashimo, Hiroshi, Kung, Patrick C., Goldstein, Gideon, Strominger, Jack L.
Format: Article
Language:English
Subjects:
Antibodies
Antigen-Antibody Complex
Antigens
Antigens, Surface
beta 2-Microglobulin - immunology
Cell lines
cell surface
Clone Cells - immunology
Electrophoresis
Epitopes
Gels
Glycoproteins - immunology
histocompatibility antigens
HLA A antigens
HLA Antigens
Humans
Immunoprecipitation
lymphocytes T
Macromolecular Substances
man
Molecular Weight
Monoclonal antibodies
Protein Conformation
T lymphocytes
T-Lymphocytes - immunology
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Summary:Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is associated with a Mr12,000 subunit that crossreacts serologically with β2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr46,000 protein associated with a small subunit distinct from β2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a β2-microglobulin-associated glycoprotein of Mr43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoeitic cell lines tested.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.78.6.3858