Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndrome

We hypothesized that the association of high sensitivity C-reactive protein (CRP) with urinary albumin excretion (UAE) is predominately mediated through its correlation with the metabolic syndrome. Serum CRP and urine albumin:creatinine ratios (ACR) from 720 preventive cardiology patients were analy...

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Bibliographic Details
Published in:The American journal of cardiology 2003-09, Vol.92 (5), p.610-612
Main Authors: Messerli, Adrian W., Seshadri, Niranjan, Pearce, Gregory L., Sachar, Ravish, Hoogwerf, Byron J., Sprecher, Dennis L.
Format: Article
Language:English
Subjects:
Age Factors
Albuminuria - etiology
Albuminuria - urine
Biological and medical sciences
Biomarkers - blood
Biomarkers - urine
C-Reactive Protein - metabolism
Cardiology. Vascular system
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cohort Studies
Coronary Disease - etiology
Coronary Disease - prevention & control
Coronary heart disease
Creatinine - urine
Diabetes Complications
Female
Heart
Humans
Hyperlipidemias - blood
Hyperlipidemias - complications
Hypertension - complications
Logistic Models
Male
Medical sciences
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - diagnosis
Metabolic Syndrome - urine
Metabolism
Middle Aged
Proteins
Risk
Risk Factors
Sensitivity and Specificity
Serum Albumin
Sex Characteristics
Smoking - adverse effects
Triglycerides - blood
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Summary:We hypothesized that the association of high sensitivity C-reactive protein (CRP) with urinary albumin excretion (UAE) is predominately mediated through its correlation with the metabolic syndrome. Serum CRP and urine albumin:creatinine ratios (ACR) from 720 preventive cardiology patients were analyzed to estimate age- and gender-adjusted relative risk of high CRP and metabolic syndrome for high ACR. These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(03)00736-7